934499-03-3Relevant articles and documents
Novel membrane-localizing TEMPO derivatives for measurement of cellular oxidative stress at the cell membrane
Ban, Shizuka,Nakagawa, Hidehiko,Suzuki, Takayoshi,Miyata, Naoki
, p. 1451 - 1454 (2007)
Oxidative stress affecting lipid membranes is considered to be closely related to cardiovascular disease and brain ischemia. In this study, we designed and synthesized membrane-localizing TEMPO derivatives and demonstrated that one of these synthesized probes, compound 1, localized and detected oxidative stress in the cell membrane in an endotoxic model of a mouse macrophage-like cell line. Compound 1 is therefore a potentially useful probe for evaluating oxidative stress at the cell membrane.