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Synthetic method of 6-hydrazino-1H-pyrazolo[3,4-b]pyridine and downstream product thereof
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Page/Page column 6-8, (2018/12/05)
The invention discloses a synthetic method of 6-hydrazino-1H-pyrazolo[3,4-b]pyridine and a downstream product thereof, and relates to the technical field of the organic chemical industry intermediatesynthesis. The synthetic method of the 6-hydrazino-1H-pyrazolo[3,4-b]pyridine comprises the following steps: firstly using easily obtained 2,6-dichloro-3-pyridylaldehyde and hydrazine hydrate as raw materials, to obtain the 6-hydrazino-1H-pyrazolo[3,4-b]pyridine, and using the 6-hydrazino-1H-pyrazolo[3,4-b]pyridine to synthesize the downstream product of 6-bromo-1H-pyrazolo[3,4-b]pyridine thereof.The synthetic method is capable of solving problems of preparing the 6-bromo-1H-pyrazolo[3,4-b]pyridine in the prior art that the raw materials are expensive and the yield is low. The route is mild in reaction condition, simple in follow-up operation, and environmentally friendly. A product is prepared in the higher yield and high purity, and the method is suitable for industrialized technology amplification.