934634-10-3Relevant academic research and scientific papers
Metabolic analysis of the cinnamate/monolignol pathway in Carthamus tinctorius seeds by a stable-isotope-dilution method
Sakakibara, Norikazu,Nakatsubo, Tomoyuki,Suzuki, Shiro,Shibata, Daisuke,Shimada, Mikio,Umezawa, Toshiaki
, p. 802 - 815 (2008/03/27)
The present study established a system for comprehensive metabolic analysis of the cinnamate/monolignol and lignan pathways by the use of a stable-isotope-dilution method. The system was successfully applied to characterization of the pathways in Carthamu
Biosynthesis of yatein in Anthriscus sylvestris.
Sakakibara, Norikazu,Suzuki, Shiro,Umezawa, Toshiaki,Shimada, Mikio
, p. 2474 - 2485 (2007/10/03)
Little is known about the biosynthesis of yatein, in spite of its importance as a typical heartwood lignan and a key biosynthetic intermediate of the antitumor lignan podophyllotoxin. The present study, based on individual administration of [13C]phenylalanine and deuterium labelled lignans and simultaneous administration of two distinct lignans labelled with deuterium atoms to Anthriscus sylvestris, established the two independent branch pathways from matairesinol, one to afford yatein via thujaplicatin, 5-methylthujaplicatin, and 4,5-dimethylthujaplicatin and the other to bursehernin via pluviatolide. The latter pathway did not lead to yatein, eliminating the presence of a metabolic grid from matairesinol to yatein.
