93467-64-2Relevant academic research and scientific papers
PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor
Hangeland, Jon J.,Abell, Lynn M.,Adam, Leonard P.,Jiang, Ji,Friends, Todd J.,Haque, Lauren E.,Neels, James,Onorato, Joelle M.,Chen, Alice Ye A.,Taylor, David S.,Yin, Xiaohong,Harrity, Thomas W.,Basso, Michael D.,Yang, Richard,Sleph, Paul G.,Gordon, David A.,Huang, Christine S.,Wexler, Ruth R.,Finlay, Heather J.,Lawrence, R. Michael
supporting information, p. 673 - 678 (2018/07/25)
Screening of a small set of nonselective lipase inhibitors against endothelial lipase (EL) identified a potent and reversible inhibitor, N-(3-(3,4-dichlorophenyl)propyl)-3-hydroxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide (5; EL IC50 = 6
PYRROLINONE CARBOXAMIDE COMPOUNDS USEFUL AS ENDOTHELIAL LIPASE INHIBITORS
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Paragraph 00178, (2013/04/13)
The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments. The disclosure also provi
PYRROLINONE CARBOXAMIDE COMPOUNDS USEFUL AS ENDOTHELIAL LIPASE INHIBITORS
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Paragraph 00191, (2013/04/13)
The present invention provides compounds of Formula (I) or Formula (III): [INSERT CHEMICAL STRUCTURE HERE] (I) [INSERT CHEMICAL STRUCTURE HERE] (III) as defined in the specification and compositions comprising any of such novel compounds. These compounds
