93468-07-6

Upstream product

• 28203-59-0 (benzylsulfonyl)acetic acid 
• 104-88-1 4-chlorobenzaldehyde 
• 100-44-7 benzyl chloride 
• 103-46-8 S-benzylmercaptoacetic acid 
• 1939-99-7 benzenesulfonyl chloride 

Downstream Products

• 1097725-27-3 methyl 4-phenylmethanesulfonyl-3-(4-chlorophenyl)butyrate 

Relevant academic research and scientific papers

(E)-4-carboxystyrl-4-chlorobenzyl sulfone and pharmaceutical compositions thereof

Pre-treatment with α,β unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone compound to a patient prior to anticancer chemotherapy with a

Styryl sulfone anticancer agents

Styryl sulfone compounds of the invention selectively inhibit proliferation of tumor cells, and induce apoptosis of tumor cells, while sparing normal cells. The compounds, which are useful in the treatment of cancer and other proliferative disorders, have

Styryl sulfone anticancer agents

Styryl sulfone compounds of the invention selectively inhibit proliferation of tumor cells, and induce apoptosis of tumor cells, while sparing normal cells. The compounds, which are useful in the treatment of cancer and other proliferative disorders, have

DESULFONYLATION OF ARYLMETHANESULFONYL CHLORIDES CATALYZED BY DICLHOROTRIS(TRIPHENYLPHOSPHINE)RUTHENIUM(II)

Reactions of arylmethanesulfonyl chlorides catalyzed by dichlorotris(triphenylphosphine)ruthenium(II) (1) have been studied.Desulfonylation occurred when arylmethanesulfonyl chlorides were treated with catalytic amounts of the ruthenium(II) catalyst to give chloromethylarene in high yields.No addition of the sulfonyl chloride to olefin was observed when the reaction was carried out in the presence of an equimolar amount of an olefin such as styrene.However, the rate of disappearance of the sulfonyl chloride was accelerated by addition of an olefin.The desulfonylation is assumed to proceed by a redox transfer promoted homolytic mechanism in the coordination sphere of the catalyst.In the presence of large excess of styrenes, arylmethanesulfonyl chlorides added to the olefins to give 1:1 adducts competitively with the desulfonylation yielding chloromethylarenes.