93468-89-4 Usage
Uses
Used in Pharmaceutical Industry:
(+/-)-BAY K 8644 is used as a research tool for studying the effects of L-type Ca2+ channel agonists on various cell types and their potential applications in treating cardiovascular and metabolic disorders. Its ability to prolong single channel open time without affecting the close time makes it valuable for investigating the role of Ca2+ channels in cellular processes.
Used in Cardiovascular Research:
(+/-)-BAY K 8644 is used as a vasoconstrictive agent for studying the mechanisms of blood vessel constriction and the potential development of drugs targeting L-type Ca2+ channels to treat cardiovascular diseases.
Used in Metabolic Research:
(+/-)-BAY K 8644 is used as a β-cell proliferation/regeneration promoter for investigating its potential role in the treatment of diabetes and improving insulin secretion by pancreatic β-cells.
Used in Neuroendocrine Research:
(+/-)-BAY K 8644 is used as a neuroendocrine cell stimulator for studying the effects of Ca2+ channel agonists on hormone secretion and the regulation of various physiological processes.
Used in Muscle Research:
(+/-)-BAY K 8644 is used as a muscle cell modulator for understanding the role of L-type Ca2+ channels in muscle contraction and relaxation, as well as their potential applications in muscle-related disorders.
Biochem/physiol Actions
Primary TargetL-type Ca2+ channel
Check Digit Verification of cas no
The CAS Registry Mumber 93468-89-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,3,4,6 and 8 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 93468-89:
(7*9)+(6*3)+(5*4)+(4*6)+(3*8)+(2*8)+(1*9)=174
174 % 10 = 4
So 93468-89-4 is a valid CAS Registry Number.
93468-89-4Relevant academic research and scientific papers
Syntheses, calcium channel agonist-antagonist modulation activities, nitric oxide release, and voltage-clamp studies of 2-nitrooxyethyl 1,4-dihydro-2,6-dimethyl- 3-nitro-4-(2-trifluoromethylphenyl)pyridine-5-carboxylate enantiomers
Shan, Rudong,Howlett, Susan E.,Knaus, Edward E.
, p. 955 - 961 (2007/10/03)
The novel (-)-(S)-2 and (+)-(R)-3 enantiomers of 2-nitrooxyethyl 1,4-dihydro-2,6-dimethyl- 3-nitro-4-(2-trifluoromethylphenyl)pyridine-5-carboxylate were synthesized for evaluation as calcium channel modulators. Determination of their in vitro calcium-cha
The design of (-)-(S)-2-nitrooxyethyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)pyridine-5-carboxyla te: A cardioselective positive inotropic derivative of Bay K 8644
Shan, Rudong,Knaus, Edward E.
, p. 2613 - 2614 (2007/10/03)
The title compound, (-)-(S)-9, is a novel cardioselective calcium channel modulator that exhibits a calcium channel agonist effect on heart, a weak calcium channel antagonist effect on smooth muscle, and releases nitric oxide in vitro. (-)-(S)-9 is a usef
