934767-95-0Relevant academic research and scientific papers
Highly regioselective synthesis of novel aromatic esters of arbutin catalyzed by immobilized lipase from Penicillium expansum
Yang, Rong-Ling,Li, Ning,Ye, Min,Zong, Min-Hua
experimental part, p. 41 - 44 (2010/12/19)
Ester derivatives of phenolic glycosides have attracted more attention in food, cosmetic and pharmaceutical industries, due to their potent biological activities. In the present study, a group of novel aromatic esters of arbutin were successfully synthesized by using immobilized lipase from Penicillium expansum with excellent 6′-regioselectivities (>99%) and moderate to excellent isolated yields (68-93%), except for 6′-O-vanilloyl-arbutin and 6′-O-(p-hydroxycinnamoyl)-arbutin with 28% and 34% yields, respectively. Among all the acyl donors tested, the lipase was most active towards vinyl 3-phenylpropionate, while remarkable decrease in the activity was recorded when the phenyl of acyl donors carried the hydroxyl and/or methoxyl.
