934816-34-9

Upstream product

• 141436-58-0 (-)-(1R)-1-[(4R,5S)-5-((1S)-1-hydroxyallyl)-2,2-dimethyl[1,3]dioxolan-4-yl]ethane-1,2-diol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 130222-84-3 5-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-D-ribono-1,4-lactone 
• 1826-67-1 vinyl magnesium bromide 
• 96690-02-7 5-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-D-ribofuranose 
• 174498-56-7 (3aR,6R,6aR)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-4-vinyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ol 

Downstream Products

• 163226-45-7 (3aS,4S,6aR)-2,2-dimethyl-6-[(triphenylmethoxy)methyl]-2H,3aH,4H,6aH-cyclopenta[d][1,3]dioxol-4-ol 
• 934816-37-2 4-[1-((tert-butyldimethylsilanyl)oxyl)allyl]-5-[1-(((tert-butyldiphenylsilanyl)oxy)methyl)vinyl]-2,2-dimethyl-[1,3]dioxolane 
• 934816-36-1 1-{5-[1-((tert-butyldimethylsilanyl)oxyl)allyl]-2,2-dimethyl[1,3]dioxolan-4-yl}-2-((tert-butyldiphenylsilanyl)oxy)ethanone 
• 878479-19-7 1-(2,2-dimethyl-6-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl)-1H-1,2,4-triazole-3-carboxylic acid amide 
• 878479-21-1 1-(2,2-dimethyl-6-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl)-1H-1,2,3-triazole-4-carboxylic acid amide 
• 878479-16-4 1-(2,2-dimethyl-6-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl)-1H-1,2,4-triazole-3-carboxylic acid methyl ester 
• 878479-17-5 1-(2,2-dimethyl-6-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl)-1H-imidazole-4-carboxylic acid methyl ester 
• 878479-18-6 1-(2,2-dimethyl-6-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl)-1H-1,2,3-triazole-4-carboxylic acid methyl ester 
• 878479-20-0 1-(2,2-dimethyl-6-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl)-1H-imidazole-4-carboxylic acid amide 
• 925672-01-1 (1S,2R,3R)-2,3-(isopropylidenedioxy)-4-(trityloxymethyl)-4-cyclopenten-1-yl methanesulfonate 
• 878479-15-3 4-azido-2,2-dimethyl-6-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxole 
• 934816-35-0 1-{5-[1-((tert-butyldimethylsilanyl)oxyl)allyl]-2,2-dimethyl[1,3]dioxolan-4-yl}-2-((tert-butyldiphenylsilanyl)oxy)ethanol 

Relevant academic research and scientific papers

Asymmetric total synthesis of (+)-gabosine C and (+)-4-epi-gabosine J using acetate migration and RCM reaction

A concise, unified and stereoselective total synthesis of (+)-gabosine C and (+)-4-epi-gabosine J from a common polyhydroxylated cyclohexenol intermediate which was synthesized from readily available D-ribose has been described. The synthetic avenue includes stereoselective Grignard reaction, silyl ether deprotection followed by acetate migration, RCM reaction, oxidative diol cleavage, hydroxymethylation and oxidative rearrangement as key steps.

INTERMEDIATES AND METHODS FOR MAKING ZEARALENONE MACROLIDE ANALOGS

Disclosed herein are methods and intermediates useful in the preparation of macrolides, e.g., compounds of formula (IV) wherein R1-R12 are as defined herein.

Synthesis of cyclopentenyl carbocyclic nucleosides as potential antiviral agents against orthopoxviruses and SARS

A practical and convenient methodology for the synthesis of chiral cyclopentenol derivative (+)-12a has been developed as the key intermediate that was utilized for the synthesis of biologically active carbocyclic nucleosides. The selective protection of

Diastereoselective reduction of hemiacetals derived from 2,3-o-isopropylidene derivatives of carbohydrate lactones

Reactions of organomagnesium and/or organolithium reagents with 2,3-O-isopropylidene-D-erythronolactone and 5-O-tertbutyldiphenylsilyl-2,3-O-isopropylidene-D-ribonolactone gave good yields of the corresponding hemiacetals which, by choice of hydride reage