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Usage

Uses

Used in Pharmaceutical Research and Drug Development:
4-Hydroxy-3,5-dimethylphenylboronic acid is utilized as a key intermediate in the synthesis of pharmaceutical compounds due to its ability to form strong and selective bonds with biological targets. This feature is crucial for the development of new drugs with enhanced efficacy and selectivity.
Used in Organic Synthesis:
In the field of organic synthesis, 4-Hydroxy-3,5-dimethylphenylboronic acid serves as a valuable building block for the formation of complex organic molecules. Its reactivity in creating carbon-carbon and carbon-heteroatom bonds is instrumental in assembling a wide range of chemical structures.
Used in Materials Science:
4-Hydroxy-3,5-dimethylphenylboronic acid is applied in materials science for the development of new materials with unique properties. Its incorporation into polymers and other materials can lead to advancements in areas such as electronics, coatings, and composites.
Used in Catalysis:
As a component in catalytic systems, 4-Hydroxy-3,5-dimethylphenylboronic acid can enhance the efficiency of chemical reactions, making industrial processes more sustainable and cost-effective.
Used in Sensor and Diagnostic Tool Development:
4-Hydroxy-3,5-dimethylphenylboronic acid is employed in the creation of sensors and diagnostic tools, capitalizing on its ability to selectively interact with specific biological molecules. This application is particularly relevant in the fields of medical diagnostics and environmental monitoring.

Upstream product

• 13675-18-8 tetrahydroxydiboron 
• 2374-05-2 4-bromo-2,6-dimethyl-phenol 
• 269410-25-5 2,6-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-phenol 

Downstream Products

• 1309682-18-5 4-(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)-2,6-dimethylphenol 
• 269410-25-5 2,6-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-phenol 

Relevant academic research and scientific papers

Bedford-type palladacycle-catalyzed miyaura borylation of aryl halides with tetrahydroxydiboron in water

A mild aqueous protocol for palladium catalyzed Miyaura borylation of aryl iodides, aryl bromides and aryl chlorides with tetrahydroxydiboron (BBA) as a borylating agent is developed. The developed methodology requires low catalyst loading of Bedford-type palladacycle catalyst (0.05 mol %) and works best under mild reaction conditions at 40 °C in short time of 6 h in water. In addition, our studies show that for Miyaura borylation using BBA in aqueous condition, maintaining a neutral reaction pH is very important for reproducibility and higher yields of corresponding borylated products. Moreover, our protocol is applicable for a broad range of aryl halides, corresponding borylated products are obtained in excellent yields up to 93% with 29 examples demonstrating its broad utility and functional group tolerance.

NOVEL COMPOUNDS FOR THE TREATMENT OF CANCER

The present invention relates to novel compounds showing an inhibitory effect on Mps-1 kinase, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.

Triazolopyridine derivates

The present invention relates to triazolopyridine compounds of general formula (I) which are Monopolar Spindle 1 kinase (Mps-1 or TTK) inhibitors: in which R1, R2, R3, R4, and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of proliferative diseases, as well as to intermediate compounds useful in the preparation of said compounds.