934826-20-7

Basic information

• Product Name: 4-Hydroxy-3,5-dimethylphenylboronic acid
• Synonyms: 4-Hydroxy-3,5-dimethylphenylboronic acid;3,5-Dimethyl-4-hydroxyphenylboronic acid
• CAS NO: 934826-20-7
• Molecular Formula: C₈H₁₁BO₃
• Molecular Weight: 165.98214
• Mol File: 934826-20-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 366.6±52.0 °C(Predicted)
• Appearance: /
• Density: 1.21±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 9.22±0.11(Predicted)
• CAS DataBase Reference: 4-Hydroxy-3,5-dimethylphenylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy-3,5-dimethylphenylboronic acid(934826-20-7)
• EPA Substance Registry System: 4-Hydroxy-3,5-dimethylphenylboronic acid(934826-20-7)

Safety Data

• Hazardous Substances Data: 934826-20-7(Hazardous Substances Data)

Usage

General Description

4-Hydroxy-3,5-dimethylphenylboronic acid is a chemical compound that consists of a boronic acid functional group attached to a phenyl ring with two methyl groups and a hydroxy group as substituents. It is commonly used as a building block in organic synthesis, particularly in the formation of carbon-carbon and carbon-heteroatom bonds. 4-Hydroxy-3,5-dimethylphenylboronic acid has been utilized in pharmaceutical research and drug development due to its ability to form strong and selective interactions with biological molecules. Additionally, 4-Hydroxy-3,5-dimethylphenylboronic acid has been studied for its potential applications in materials science, catalysis, and the development of sensors and diagnostic tools.

Upstream product

• 13675-18-8 tetrahydroxydiboron 
• 2374-05-2 4-bromo-2,6-dimethyl-phenol 
• 269410-25-5 2,6-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-phenol 

Downstream Products

• 1309682-18-5 4-(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)-2,6-dimethylphenol 
• 269410-25-5 2,6-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-phenol 

Relevant articles and documents

Bedford-type palladacycle-catalyzed miyaura borylation of aryl halides with tetrahydroxydiboron in water

A mild aqueous protocol for palladium catalyzed Miyaura borylation of aryl iodides, aryl bromides and aryl chlorides with tetrahydroxydiboron (BBA) as a borylating agent is developed. The developed methodology requires low catalyst loading of Bedford-type palladacycle catalyst (0.05 mol %) and works best under mild reaction conditions at 40 °C in short time of 6 h in water. In addition, our studies show that for Miyaura borylation using BBA in aqueous condition, maintaining a neutral reaction pH is very important for reproducibility and higher yields of corresponding borylated products. Moreover, our protocol is applicable for a broad range of aryl halides, corresponding borylated products are obtained in excellent yields up to 93% with 29 examples demonstrating its broad utility and functional group tolerance.

Triazolopyridine derivates

The present invention relates to triazolopyridine compounds of general formula (I) which are Monopolar Spindle 1 kinase (Mps-1 or TTK) inhibitors: in which R1, R2, R3, R4, and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of proliferative diseases, as well as to intermediate compounds useful in the preparation of said compounds.