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Asymmetric synthesis of the (S)-1,1-dioxido-isothiazolidin-3-one phosphotyrosine mimetic via reduction of a homochiral (R)-oxido-isothiazolidin- 3-one
Combs, Andrew P.,Glass, Brian,Galya, Laurine G.,Li, Mei
, p. 1279 - 1282 (2008/01/03)
Figure presented The first asymmetric synthesis of the (S)-1,1-dioxido- isothiazolidin-3-one ((S)-IZD) pTyr mimetic, which has been incorporated into the recently reported potent protein tyrosine phosphatase 1B (PTP1B) inhibitors, is presented herein. The
