934972-77-7

Basic information

• Product Name: 3-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-3-methyl-N-[(1S,2R)-2-(3-chlorophenyl)cyclopropyl]butanamide
• CAS NO: 934972-77-7
• Molecular Weight: 402.924
• Mol File: 934972-77-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-3-methyl-N-[(1S,2R)-2-(3-chlorophenyl)cyclopropyl]butanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-3-methyl-N-[(1S,2R)-2-(3-chlorophenyl)cyclopropyl]butanamide(934972-77-7)
• EPA Substance Registry System: 3-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-3-methyl-N-[(1S,2R)-2-(3-chlorophenyl)cyclopropyl]butanamide(934972-77-7)

Safety Data

• Hazardous Substances Data: 934972-77-7(Hazardous Substances Data)

Upstream product

• 934972-86-8 tert-butyl (2-methyl-4-{[(1S,2R)-2-(3-chlorophenyl)-cyclopropyl]amino}-4-oxobutan-2-yl)carbamate 
• 207557-33-3 (S)-1-bromoacetyl-2-pyrrolidinecarbonitrile 

Relevant articles and documents

Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors

A series of trans-2-aryl-cyclopropylamine derived compounds were synthesized and evaluated their biological activities against DPP-IV. The structure-activity relationships (SAR) led to the discovery of novel series of DPP-IV inhibitors, having IC50 values of 100 nM with excellent selectivity over the closely related enzymes, DPP8, DPP-II and FAP. The studies identified a potent and selective DPP-IV inhibitor 24b, which exhibited the ability to both significantly inhibit plasma DPP-IV activity in rats and improve glucose tolerance in lean mice and diet induced obese mice.