934989-16-9Relevant academic research and scientific papers
Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4′-piperidine] based melanocortin subtype-4 receptor agonists
Guo, Liangqin,Ye, Zhixiong,Liu, Jian,He, Shuwen,Bakshi, Raman K.,Sebhat, Iyassu K.,Dobbelaar, Peter H.,Hong, Qingmei,Jian, Tianying,Dellureficio, James P.,Tsou, Nancy N.,Ball, Richard G.,Weinberg, David H.,MacNeil, Tanya,Tang, Rui,Tamvakopoulos, Constantin,Peng, Qianping,Chen, Howard Y.,Chen, Airu S.,Martin, William J.,MacIntyre, D. Euan,Strack, Alison M.,Fong, Tung M.,Wyvratt, Matthew J.,Nargund, Ravi P.
scheme or table, p. 4895 - 4900 (2010/10/02)
Design, synthesis, and SAR of a series of 3H-spiro[isobenzofuran-1, 4′-piperidine] based compounds as potent, selective and orally bioavailable melanocortin subtype-4 receptor (MC4R) agonists are disclosed.
ACYLATED SPIROPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS
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Page/Page column 71, (2010/11/27)
Certain novel N-acylated spiropiperidine derivatives are ligands of the human melanocortin receptor(s) and, in particular, are selective ligands of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of MC-4R, such as obesity, diabetes, nicotine addiction, alcoholism, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
