935-69-3

Basic information

• Product Name: 7-METHYLADENINE
• Synonyms: 6-AMINO-7-METHYLPURINE;7-METHYLADENINE;7-METHYL-7H-PURIN-6-AMINE;Adenine, 7-methyl-;N7-Methyladenine;7-Methyladenine90%;7H-Purin-6-amine, 7-methyl- (9CI);7-Methyladenine, HPLC 90%
• CAS NO: 935-69-3
• Molecular Formula: C₆H₇N₅
• Molecular Weight: 149.15
• Product Categories: PYRIMIDINE;Nucleic acids
• Mol File: 935-69-3.mol
• Article Data: 13

Chemical Properties

• Melting Point: 323 °C
• Boiling Point: 260.22°C (rough estimate)
• Flash Point: 187.2°C
• Appearance: White to off-white/Powder
• Density: 1.1798 (rough estimate)
• Vapor Pressure: 3.67E-06mmHg at 25°C
• Refractive Index: 1.8070 (estimate)
• PKA: 4.73±0.30(Predicted)
• CAS DataBase Reference: 7-METHYLADENINE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-METHYLADENINE(935-69-3)
• EPA Substance Registry System: 7-METHYLADENINE(935-69-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22-43-36
• Safety Statements: 24/25-36/37-26
• WGK Germany: 3
• Hazardous Substances Data: 935-69-3(Hazardous Substances Data)

Usage

Chemical Properties

white to almost white powder

Definition

ChEBI: Adenine substituted with a methyl group at position N-7.

InChI:InChI=1/C6H7N5/c1-11-3-10-6-4(11)5(7)8-2-9-6/h2-3H,1H3,(H2,7,8,9)

Upstream product

• 40637-80-7 4-amino-5-cyano-1-methyl-1H-imidazole 
• 77287-34-4 formamide 
• 3324-79-6 7-Methyl-6-thiopurin 
• 39947-04-1 N-6-benzoyl-2',3'-O-isopropylideneadenosine 
• 66224-66-6 adenine 
• 74-88-4 methyl iodide 
• 1006-08-2 7-methyl-1,7-dihydro-purin-6-one 
• 110475-17-7 5-amino-3-methyl-3H-imidazole-4-carboxylic acid amide; hydrochloride 
• 40648-96-2 1-methyl-4-nitro-1H-imidazole-5-carbonitrile 
• 98021-35-3 5-hydroxyamino-3-methyl-3H-imidazole-4-carbonitrile 
• 7280-81-1 3-benzyladenine 
• 19399-25-8 N⁶-methoxyadenosine 
• 77868-54-3 N⁶-Benzoyl-7-methyl-9-(2,3-O-isopropylidene-β-D-ribofuranosyl)-adeninium iodide 
• 362-75-4 2',3'-isopropylidene adenosine 

Downstream Products

• 5155-12-4 4-amino-N-(7-methyl-7H-purin-6-yl)-benzenesulfonamide 

Relevant articles and documents

Peptide deformylase inhibitors

The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhibition of bacterial peptide deformylase (PDF) activity.

8-(2-Furyl)adenine derivatives as A2A adenosine receptor ligands

Selective adenosine receptor modulators are potential tools for numerous therapeutic applications, including cardiovascular, inflammatory, and neurodegenerative diseases. In this work, the synthesis and biological evaluation at the four human adenosine receptor subtypes of a series of 9-substituted 8-(2-furyl)adenine derivatives are reported. Results show that 8-(2-furyl)-9-methyladenine is endowed with high affinity at the A2A subtype. Further modification of this compound with introduction of arylacetyl or arylcarbamoyl groups in N6-position takes to different effects on the A2A affinity and in particular on the selectivity versus the other three adenosine receptor subtypes. A molecular modelling analysis at three different A2A receptor crystal structures provides an interpretation of the obtained biological results.

Purines. LXXV. Dimroth rearrangement, hydrolytic deamination, and pyrimidine-ring breakdown of 7-alkylated 1-alkoxyadenines: N(1)-C(2) versus N(1)-C(6) bond fission

On treatment with boiling H2O for 5-6h, 1-alkoxy-7-alkyladenines (13) underwent hydrolytic cleavage of the N(1)-C(2) and the N(1)-C(6) bonds to produce the imidazole-5-carboxamidines (14) in 53-60% yields and the imidazole-5-carboxamides (18) i