935-77-3

Usage

General Description

1H-Inden-1-one, 2,3-dihydro-3-methyl-, (3S)-, also known as 3S-2,3-dihydro-3-methyl-1H-inden-1-one, is a chemical compound with the molecular formula C10H10O. It is a chiral molecule, meaning it has a specific spatial arrangement of atoms, and the (3S)- designation refers to its stereochemistry. 1H-Inden-1-one, 2,3-dihydro-3-methyl-, (3S)- is commonly used in the production of fragrances and perfumes due to its pleasant odor. It may also have potential applications in pharmaceuticals and organic synthesis. Additionally, it is a colorless to pale yellow liquid at room temperature and is relatively stable under normal conditions.

Upstream product

• 4593-90-2 (S)-2-phenylbutanoic acid 
• 68679-84-5 (S)-3-phenyl butyric acid chloride 
• 40774-41-2 3-Bromoindan-1-one 
• 74-88-4 methyl iodide 
• 23417-79-0 2-(1-methylethenyl)benzaldehyde 
• 32523-78-7 (1R,3S)-3-methyl-2,3-dihydro-1H-inden-1-ol 
• 6072-57-7 3-methylindanone 
• 100-58-3 phenylmagnesium bromide 
• 4593-90-2 3-phenylbutyric acid 
• 113675-84-6 (4R,5S)-1,5-Dimethyl-4-phenyl-3-((S)-3-phenyl-butyryl)-imidazolidin-2-one 
• 83-33-0 inden-1-one 
• 40138-16-7 2-formylbenzene boronic acid 

Downstream Products

• 767-58-8 (-)-(S)-1-methylindane 
• 170941-14-7 (+)-(S)-5-fluoro-1-methylindene 
• 82309-95-3 (1R,2S)-2t-Benzyl-1r-methyl-2c-indanmethanol 
• 82309-96-4 (1R,2S)-2t-Benzyl-1r-methyl-2c-indancarbonsaeure 
• 82309-93-1 (2S,3R)-2t-Benzyl-2c-(hydroxymethyl)-3r-methyl-1t-indanol 
• 82252-91-3 (1R,2S)-2c-(Acetoxymethyl)-2t-benzyl-1r-methylindan 
• 82252-89-9 (R,R)-2t-Benzyl-1r-methyl-3-oxo-2c-indancarbonsaeure-ethylester 
• 1286745-31-0 (S)-benzoic acid 2-(3-hydroxy-1-methylpropyl)phenyl ester 
• 1286745-32-1 (S)-benzoic acid 2-(3-iodo-1-methylpropyl)phenyl ester 
• 1286745-33-2 (S)-benzoic acid 2-sec-butylphenyl ester 
• 1286745-34-3 (S)-3-sec-butyl-2-hydroxybenzaldehyde 
• 1286745-35-4 (S)-3-sec-butyl-2-hydroxy-5-iodobenzaldehyde 
• 1286745-30-9 (S,S)-1,4-bis((5-sec-butyl-4-hydroxy-3-formylphenyl)ethynyl)benzene 
• 159650-89-2 (+)-(S)-2-sec-butylphenol 

Relevant academic research and scientific papers

Mild, efficient friedel-Crafts acylations from carboxylic acids using cyanuric chloride and AlCl3

(Chemical Equation Presented) A mild method for Friedel-Crafts acylation with aromatic and aliphatic carboxylic acids using cyanuric chloride, pyridine, and AlCl3 was developed. Both inter- and intramolecular acylations were achieved at room temperature in high yield and in very short reaction times.

Exploring the synthetic potential of a marine transaminase including discrimination at a remote stereocentre

The marine transaminase, P-ω-TA, can be employed for the transamination from 1-aminotetralins and 1-aminoindanes with differentiation of stereochemistry at both the site of reaction and at a remote stereocentre resulting in formation of ketone products with up to 93% ee. While 4-substituents are tolerated on the tetralin core, the presence of 3- or 8-substituents is not tolerated by the transaminase. In general P-ω-TA shows capacity for remote diastereoselectivity, although both the stereoselectivity and efficiency are dependent on the specific substrate structure. Optimum efficiency and selectivity are seen with 4-haloaryl-1-aminotetralins and 3-haloaryl-1-aminoindanes, which may be associated with the marine origin of this enzyme. This journal is

CYCLIC TETRAMER COMPOUNDS AS PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) INHIBITORS FOR THE TREATMENT OF METABOLIC DISORDERS

The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein R1, R1, R1, R1, R1, R1, R1, R1, R1, X1, X2, and X3 are described herein.

Asymmetric Induction in Hydroacylation by Cooperative Iminium Ion-Transition-Metal Catalysis

A new strategy for the rhodium-catalyzed enantioselective hydroacylation is described. This has been achieved through the merger of iminium ion catalysis and transition-metal catalysis such that asymmetric induction derives from a readily accessible, inexpensive chiral nonracemic secondary amine catalyst rather than a chiral nonracemic phosphine as is typical of conventional asymmetric hydroacylation methods.

Cobalt-catalyzed enantioselective intramolecular hydroacylation of ketones and olefins

Cobalt-chiral diphoshine catalytic systems promote intramolecular hydroacylation reactions of 2-acylbenzaldehydes and 2-alkenylbenzaldehydes to afford phthalide and indanone derivatives, respectively, in moderate to good yields with high enantioselectivities. The ketone hydroacylation did not exhibit a significant H/D kinetic isotope effect (KIE) with respect to the aldehyde C-H bond, indicating that C-H activation would not be involved in the rate-limiting step.

Controlling chiral organization of molecular rods on Au(111) by molecular design

Chiral self-assembled structures formed from organic molecules adsorbed on surfaces have been the subject of intense investigation in the recent decade, owing both to relevance in applications such as enantiospecific heterogeneous catalysis or chiral sepa

Synthesis of Chiral 3-Alkyl-3,4-dihydroisocoumarins by dynamic kinetic resolutions catalyzed by a Baeyer-Villiger Monooxygenase

"Chemical Equation Presented" Baeyer-Villiger monooxygenases have been tested, in the oxidation of racemic benzofused ketones. When employing a single mutant of phenylacetone monooxygenase (M.446G PAMO) under the proper reaction conditions, it was possible to achieve 3-substituted 3,4-dihydroisocoumarins with, high yields and optical purities through regioselective dynamic kinetic resolution processes.

Rh(I)-catalyzed intramolecular hydroacylation in ionic liquids

Rh(I)-catalyzed hydroacylation of 4-alkenal or 4,6-dienal using ionic liquids (ILs) as reaction media proceeded smoothly, giving cyclopentanone or cycloheptenone derivatives in good yields. It was found that the IL recovered after the reaction, which shou

Asymmetric reduction of substituted indanones and tetralones catalyzed by chiral dendrimer and its application to the synthesis of (+)-sertraline

A recoverable dendrimeric supported prolinol was used as a catalyst in the asymmetric reduction of indanones and tetralones to give separable cis and trans isomers up to 97% ee. This method was also applied in the enantioselective synthesis of the antidepressant drug (+)-sertraline.

Hydroacylation of 2-vinyl benzaldehyde systems: An efficient method for the synthesis of chiral 3-substituted indanones

Asymmetric rhodium-catalyzed hydroacylation has been utilized in the synthesis of 3-substituted indanones with high conversions and enantioselectivity. The hydroacylation reaction of 2-vinyl benzaldehyde had been previously reported to give a low yield of indanone and an unidentified product. We have identified this compound as a dimer of the starting material. Substitution at the α-position of the 2-vinyl benzaldehyde substrates blocks the competitive dimerization reaction and allows the reaction to proceed with yields generally greater than 90%. Utilization of BINAP as a chiral ligand results in good chemical yields and enantioselectivity greater than 95% in most cases. Copyright