935-91-1Relevant academic research and scientific papers
The glutamate receptor GluR5 agonist (S)-2-Amino-3-(3-hydroxy-7,8-dihydro- 6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: Synthesis, molecular pharmacology, and biostructural characterization
Clausen, Rasmus P.,Naur, Peter,Kristensen, Anders S.,Greenwood, Jeremy R.,Strange, Mette,Brauner-Osborne, Hans,Jensen, Anders A.,Nielsen, Anne Sophie T.,Geneser, Ulla,Ringgaard, Lone M.,Nielsen, Birgitte,Pickering, Darryl S.,Brehm, Lotte,Gajhede, Michael,Krogsgaard-Larsen, Povl,Kastrup, Jette S.
experimental part, p. 4911 - 4922 (2010/03/03)
The design, synthesis, and pharmacological characterization of a highly potent and selective glutamate GluR5 agonist is reported. (S)-2-Amino-3-((RS)-3- hydroxy-8-methyl-7,8-dihydro-6H-cyclohepta-[d]isoxazol-4-yl)propionic acid (5) is the 8-methyl analogu
