93503-08-3

Usage

Uses

Used in Pharmaceutical Research:
(R)-(+)-7-methoxy-N-propyl-2-aminotetraline hydrochloride is used as a research tool for studying the 5-HT1A receptor and its role in various physiological and pathological processes. (R)-(+)-7-methoxy-N-propyl-2-aminotetraline hydrochloride helps researchers understand the receptor's function and its involvement in different health conditions.
Used in Treatment of Serotonin-Related Disorders:
(R)-(+)-7-methoxy-N-propyl-2-aminotetraline hydrochloride is used as a potential therapeutic agent for conditions related to serotonin signaling, such as depression, anxiety, and schizophrenia. Its agonist properties allow it to modulate the 5-HT1A receptor, which is implicated in these disorders, potentially leading to improved treatment options.
Used in Drug Development:
As a valuable tool for understanding and developing new treatments for serotonin-related disorders, (R)-(+)-7-methoxy-N-propyl-2-aminotetraline hydrochloride is used in the development of novel pharmaceuticals. Its interaction with the 5-HT1A receptor provides insights into the design of more effective and targeted medications for various mental health conditions.

Downstream Products

• 82730-72-1 R-(+)-7-hydroxy-2-dipropylaminotetraline 

Relevant academic research and scientific papers

Further delineation of hydrophobic binding sites in dopamine D 2/D3 receptors for N-4 substituents on the piperazine ring of the hybrid template 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5, 6,7,8-tetrahydro-naphthalen-2-ol

Here we report a structure-activity relationship (SAR) study of analogues of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro- naphthalen-2-ol. Our SAR is focused on introduction of various substitutions in the piperazine ring of the hybrid template. The goal behind this study is to delineate the nature of the binding pocket for N-aryl substitution in the piperazine ring by observing the effect of various hydrophobic and other heteroaromatic substitutions on binding affinity (Ki), as measured with tritiated spiperone and HEK-293 cells expressing either D2 or D3 receptors. Functional activity of selected compounds was assessed with the GTPγS binding assay. Compound 8d was the most selective for the D3 receptor in the spiperone binding assay. An interesting similarity in binding affinity was observed between isoquinoline derivative D-301 and the 2-substituted pyridine derivative 8d, suggesting the importance of relative spatial relationships between the N-atom of the ligand and the molecular determinants of the binding pocket in D2/D3 receptors. Functional activity assays demonstrated high potency and selectivity of (+)-8a and (-)-28b (D2/D3 (ratio of EC50): 105 and 202, respectively) for the D3 receptor and both compounds were more selective compared to the reference drug ropinirole (D2/D3 (ratio of EC50): 29.5).