93513-92-9Relevant academic research and scientific papers
Phototransformations of some 3-cyclohexenyloxychromenones: Synthesis of Spirocyclic compounds
Khanna, Radhika,Dalal, Aarti,Berar, Urmila,Singh, Sandeep,Kamboj, Ramesh C.
, p. 668 - 673 (2019/01/05)
The phototransformation of the 3-cyclohexenyloxychromenones by irradiation with a pyrex-filtered light from a 125 W Hg vapor lamp under an inert atmosphere into the spirocyclic fused xanthenones was described. The efficacy of the protocol depended upon th
5′-Chloro-2,2′-dihydroxychalcone and related flavanoids as treatments for prostate cancer
Saito, Yohei,Mizokami, Atsushi,Tsurimoto, Hiroyuki,Izumi, Kouji,Goto, Masuo,Nakagawa-Goto, Kyoko
, p. 1143 - 1152 (2018/09/10)
Several flavonoids and their biosynthetic precursor chalcones were designed and synthesized to improve the biological effects of the lead compound 2′-hydroxyflavonone against androgen receptor (AR)-dependent transcriptional stimulation. Newly synthesized chalcones 19 and 26 suppressed AR-dependent transcription as well as DHT-dependent growth stimulation at a low micromolar level. These compounds were also effective against ligand-independent constitutively active mutant AR derived from castration-resistant PCa (CRPC). Compounds 19 and 26 showed broad spectrum antiproliferative activity at 5–10 μM against multiple tumor cell lines including androgen-independent and taxane-resistant prostate cancer as well as a multidrug-resistant subline. Mode of action studies suggested that 19 induced sub-G1 accumulation in PC-3 cells by disrupting the microtubule network without affecting cell cycle progression. Furthermore, the in vivo effectiveness of chalcone 19 was confirmed in a xenograft model antitumor assay. Thus, chalcone 19 has the potential to be a bifunctional lead for treatment of AR-dependent PCa at lower doses as well as AR-independent PCa, including CRPC, at higher doses.
Synthesis and biological activities of some new quinoxalines
Basawaraj, Raga,Alvi, Shah Nadeemuddin,Chillargi, Neelavati,Gahininath, Wadikar,Zaheeruddin
, p. 147 - 150 (2013/09/24)
The condensation of 5-chloro-2-hydroxyacetophenone 1 with different substituted aromatic aldehydes in ethanol in presence of strong alkali furnished 1-(2-hydroxy-5-chlorophenyl)-3-aryl propen-1-ones 2a-e. Bromination of compounds 2a-e in acetic acid gave 1-(2-hydroxy-5-chlorophenyl)-3-aryl 2,3-dibromopropan-1-ones 3a-e which upon treatment with o-phenylenediamine in methanol in presence of cone sulphuric acid underwent cyclization and resulted in the formation of quinoxaline derivatives 4ae. Structures of compounds were established on the basis of analytical and spectral studies. Further these compounds were evaluated for their antimicrobial activities and some selected compounds were evaluated for antitubercular activities.
Photo-reorganization of some 3-alkoxy-2-(alkoxyphenyl)chromones
Kamboj, Ramesh C.,Berar, Urmila,Berar, Surinder,Thakur, Mandeep,Gupta, Satish C.
scheme or table, p. 685 - 691 (2009/12/24)
A photo-reorganization of 3-alkoxy-2-(alkoxyphenyl)chromones to the isomeric angular tetracyclic compounds through the 1,4-biradical generated by the excited carbonyl group through tlie γ-hydrogen abstraction has been described. Substituent effect of the
