93515-16-3Relevant academic research and scientific papers
The efficient synthesis of Hantzsch 1,4-dihydropyridines via metal-free oxidative C–C coupling by HBr and DMSO
Rezaei, Narjes,Ranjbar, Parviz Rashidi
, p. 4102 - 4106 (2018/10/20)
A novel and efficient synthesis of Hantzsch 1,4-dihydropyridines through metal-free oxidative C–C coupling process was described. The reaction between benzylic alcohols, 1,3-dicarbonyl compounds and ammonium hydroxide in the presence of HBr in DMSO at 75 °C led to afford 1,4-dihydropyridine in excellent yields. This protocol introduces the use of benzyl alcohols instead of aldehydes as a new modification of the Hantzsch reaction.
Synthesis of 1,4-dihydropyridines and their hypotensive activity
Shinde, D. B.,Shinde, N. D.,Shingare, M. S.,Dubey, M. P.,Patnaik, G. K.
, p. 920 - 922 (2007/10/03)
1,4-Dihydropyridines (1-35) have been synthesised by treating different aldehydes with dicarbonyl compounds and ammonium hydroxide and are found to possess hypotensive activity.
1,4-Dihydropyridine antagonist activities at the calcium channel: A quantitative structure-activity relationship approach
Coburn,Wierzba,Suto,Solo,Triggle,Triggle
, p. 2103 - 2107 (2007/10/02)
The effect of 46 1,4-dihydropyridine-type calcium channel antagonists on the tonic contractile response of longitudinal muscle strips of guinea pig ileum was determined. 2,6-Dimethyl-3,5-dicarbomethoxy-4-phenyl-1,4-dihydropyridine (13) and 13 ortho-, 15 meta-, and seven para-monosubstituted and 10 polysubstituted aromatic derivatives of 13 were studied. The pharmacological activities of the monosubstituted derivatives were best correlated by eq 10, log 1/C = 0.68π + 2.50σ(m) - 0.47L(meta) - 3.40B1(para) + 11.31, which had a correlation coefficient of 0.89. The full data set was best correlated by eq 11, log 1/C = 0.62π + 1.96σ(m) - 0.44L(meta) - 3.26B1(para) - 1.51L(meta) + 14.23, which had a correlation coefficient of 0.90. Equations of similar form but involving an ortho steric term were found to correlate the radioligand binding data for this class of compounds.
