93515-65-2

Upstream product

• 3425-46-5 potassium selenocyanate 
• 874-60-2 4-methyl-benzoyl chloride 

Downstream Products

• 905996-51-2 2-phenyl-5-p-tolyl-1,2-dihydro-3H-1,2,4-triazole-3-selone 
• 905996-57-8 1-phenyl-4-p-toluoylselenosemicarbazide 

Relevant academic research and scientific papers

Synthesis of 4-aryl-1,3,4a-triazaphenanthrene-2-selones via three-component condensation of quinolin-2-amine, potassium selenocyanate and an acyl chloride

A three-component reaction between quinolin-2-amine, potassium selenocyanate and variously substituted benzoyl chlorides in acetone at room temperature provided a simple and efficient one-pot route for the synthesis of six 4-aryl-1,3,4a-triazaphenanthrene

Iron selenide nanoparticles coated on carbon nanotubes from single source ferrocene incorporated selenourea precursor for fuel cell and photocatalytic applications

This article presents the synthesis and characterization (multinuclear NMR, FTIR, CHNS, AAS and single crystal XRD) of a single source organometallic precursor namely 1-(4-methylbenzoyl)-3-(3-ferrocenylphenyl)selenourea for the fabrication of iron selenid

Ultrasound-assisted a domino three-component reaction to polycyclic selenopyrans synthesis

A novel and efficient three-component reaction of substituted benzoyl chlorides, potassium selenocyanate and vinyl malononitriles was developed for the synthesis of polycyclic selenopyrans via an ultrasound-assisted domino vinylogous nucleophilic reaction

Synthesis of 4-aryl-7-methoxy-9-thia-[1,3,4a]triazafluorene-2-selones via a three-component condensation of 6-methoxybenzothiazol-2-ylamine, potassium selenocyanate and an acyl chloride

A simple, one-pot synthesis of six 4-aryl-7-methoxy-9-thia-[1,3,4a]triazafluorene-2-selones has been achieved in moderate to good yields via a three-component condensation of 6-methoxybenzothiazol-2-ylamine, potassium selenocyanate and variously substitut

Pre-clinical evidences of the antileishmanial effects of diselenides and selenocyanates

A series of thirty-one selenocompounds covering a wide chemical space was assessed for in vitro leishmanicidal activities against Leishmania infantum amastigotes. The cytotoxicity of those compounds was also evaluated on human THP-1 cells. Interestingly most tested derivatives were active in the low micromolar range and seven of them (A.I.3, A.I.7, B.I.1, B.I.2, C.I.7 C.I.8 and C.II.8) stood out for selectivity indexes higher than the ones exhibited by reference compounds mitelfosine and edelfosine. These leader compounds were evaluated against infected macrophages and their trypanothione reductase (TryR) inhibition potency was measured to further approach the mechanism by which they caused their action. Among them diselenide tested structures were pointed out for their ability to reduce infection rates. Three of the leader compounds inhibited TryR effectively, therefore this enzyme may be implicated in the mechanism of action by which these compounds cause their leishmanicidal effect.

Synthesis of 2-aryl-7-methyl-4-selenoxo-4H-pyrano[3,4-e][1,3]oxazin-5-one via a three-component condensation

The reaction between 4-hydroxy-6-methyl-2H-pyran-2-one and aroyl chlorides with potassium selenocyanate in the presence of catalytic amounts of N-methylimidazole under solvent-free conditions provided a simple and efficient one-pot route for the synthesis

Synthesis, characterization and biological applications of selenoureas having ferrocene and substituted benzoyl functionalities

In this article we have comprehensively reported the synthesis, complete chemical characterization (FTIR, multinuclear NMR, single crystal XRD, CHNS, AAS) and biological applications of seventeen ferrocene incorporated selenoureas. Biological applications

Combined Acylselenourea-Diselenide Structures: New Potent and Selective Antitumoral Agents as Autophagy Activators

A series of 16 new diselenide-acylselenourea conjugates have been designed following the fragment-based drug strategy. Compound in vitro cytotoxic potential was evaluated against six human cancer cell lines and two nonmalignant derived cell lines with the aim of determining their potency and selectivity. Nine derivatives exhibited GI50 values under 10 μM in at least four cancer cell lines. A clear gap situated phenyl substitution over heterocyclic moieties in terms of selectivity. Among carbocyclic compounds, derivatives 2 and 7 significantly inhibited cell growth of breast adenocarcinoma cells with GI50 values of 1.30 and 0.15 nM, respectively, with selectivity indexes 12 and 121 times higher than those obtained for doxorubicin. Preliminary mechanistic studies indicated that compounds 2 and 7 induce cell cycle arrest and autophagy-dependent cell death evidenced by the blockage of cell death with pretreatment with wortmannin or chloroquine and confirmed by the upregulation of the markers Beclin1 and LC3B in MCF-7 cells.

Synthesis of 5-aryl-1,3-dimethyl-7-selenoxopyrimidino[4,5-d]pyrimidine-2,4(1H,3H)-dione

A one-pot method for the synthesis of six novel 5-aryl-1,3-dimethyl-7-selenoxopyrimidino[4,5-d]pyrimidine-2,4(1H,3H)-diones in excellent yields at room temperature has been achieved via reaction between potassium selenocyanate and an aroyl chloride follow

A one-pot synthesis of 2H-pyrido[1,2-a][1,3,5]triazine-2-selenones from acyl isoselenocyanates and pyridin-2-amine

Abstract: Acyl isoselenocyanates, prepared by acyl chlorides and potassium selenocyanate, are trapped by pyridin-2-amine to afford 4-substituted pyrido[1,2-a][1,3,5]triazine-2-selenone in moderate to good yields. Graphical abstract: [Figure not available: