93517-74-9Relevant academic research and scientific papers
POTASSIUM CHANNEL MODULATORS
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Page/Page column 43-44, (2011/06/19)
Disclosed herein are KCNQ potassium channels modulators of formula (I) wherein ring Z1, R1, p, R3, and R4 are as defined in the specification. Compositions comprising such compounds; and methods for treating conditions and disorders using such compounds and compositions are also described.
Synthesis and anti-inflammatory evaluation of some condensed [4-(3,4-dimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic acid hydrazide
Abd alla, Mosaad S.M.,Hegab, Mohamed I.,Abo Taleb, Nageh A.,Hasabelnaby, Sherifa M.,Goudah
experimental part, p. 1267 - 1277 (2010/06/12)
Some new 1,3,4-triazolo-, 1,3,4-oxadiazolo-, 1,3,4-thiadiazol-, and pyrazolo-3,4-dimethylphenyl-1(2H)-oxo-phthalazine derivatives were synthesized and identified by IR, 1H NMR, MS and elemental analysis. Most of the newly synthesized products were tested for their anti-inflammatory activities. Among them, compounds 11, 17b, 20, 21 and 22 are active compare to the activity of indomethacin.
Synthesis and some reactions of 3,4-dimethoxyphenylmethyleneaminophthalimide
Derbala, H. A. Y.
, p. 779 - 781 (2007/10/02)
3,4-Dimethoxyphenylmethyleneaminophthalimide (1) reacts with aromatic hydrocarbons under Friedel-Craft's conditions to give 4-arylphthalazin-1-ones (2a-c).The reaction involves ring cleavage followed by cyclization and elimination of the aldehyde moiety.The investigation is extended to study the reaction of the title compound with Grignard reagents and amines leading to the formation of 2a, 4-6), respectively.
REACTIONS OF 2,3-DIARYL-3-HYDROXYPHTHALIMIDINES WITH GRIGNARD REAGENTS AND HYDRAZINE HYDRATE
Ismail, Mohamed Fekry,Enayat, Ebtesam Ismail,El-Bassiouny, Fakhry Abdel Aziz,Younes, Hamed Ahmed
, p. 677 - 678 (2007/10/02)
2,3-diaryl-3-hydroxyphthalimidines, 1, react with benzylmagnesium chloride to give 3-aryl-3-benzylphthalides 2.The reaction involves the removal of the amine part at position 2.Reaction of 1a with phenylmagnesium bromide proceeded differently to give 3.Th
NEW CONVENIENT ONE-STEP SYNTHESIS OF 4-ARYLPHTHALAZ-1-ONES
Ismail, M. Fekry,El-Bassiouny, F. A.,Younes, H. A.
, p. 2983 - 2984 (2007/10/02)
4-Arylphthalaz-1-ones (2a-e) are prepared by the hitherto unknown reaction of N-aminophthalimide (1) with aromatic hydrocarbons under Friedel-Crafts conditions.The reaction of N-aminophthalimide with Grignard reagents presents another convenient method for the synthesis of 4-alkyl or 4-arylphthalaz-1-ones.
