93524-64-2Relevant academic research and scientific papers
Denitrogenative Hydrotrifluoromethylation of Benzaldehyde Hydrazones: Synthesis of (2,2,2-Trifluoroethyl)arenes
Zhao, Zhensheng,Ma, Kevin C. Y.,Legault, Claude Y.,Murphy, Graham K.
, p. 11240 - 11245 (2019/08/20)
Reacting hydrazones of arylaldehydes with Togni's CF3-benziodoxolone reagent, in the presence of potassium hydroxide and cesium fluoride, induces a denitrogenative hydrotrifluoromethylation event to produce (2,2,2-trifluoroethyl)arenes. This novel reaction was tolerant to many electronically-diverse functional groups and substitution patterns, as well as naphthyl- and heteroaryl-derived substrates. Advantages of this process include the easy access to hydrazone precursors on a large scale, speed and operational simplicity, and being transition metal-free.
Fluorine Magnetic Resonance Studies. VII. Fluorine-Fluorine Coupling Over Five Bonds in 1-Fluoro-2-(2'-fluorophenyl)ethanes
Burgess, David A.,Finn, Michael F.,Jordan, David,Rae, Ian D.,Walters, Barry D.
, p. 1769 - 1773 (2007/10/02)
Spin-spin coupling between an aromatic fluorine and fluorines in an adjacent side chain (Ar-C-C-F), with J values in the range 2-5 Hz, is reported for four new compounds.The coupling probably arises from through-space interactions taking place when rotati
