935248-50-3

Upstream product

• 935248-49-0 6-[4-(tert-butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxy)-3,3-dimethyl-butyl]-4-[(1,1-dimethyl-ethyl)-diphenyl-silanyloxy]-tetrahydropyran-2-one 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 935248-47-8 9-(tert-butyl-dimethyl-silanyloxy)-3,5-dihydroxy-7-(4-methoxy-benzyloxy)-8,8-dimethyl-nonanoic acid methyl ester 
• 935248-46-7 9-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-7-(4-methoxy-benzyloxy)-8,8-dimethyl-3-oxo-nonanoic acid methyl ester 
• 935248-45-6 (3S)-5-tert-butyldimethylsilyloxy-3-(4-methoxybenzyloxy)-4,4-dimethylpentanal 
• 935248-43-4 (3S)-1-tert-butyldimethylsilyloxy-3-(4-methoxybenzyloxy)-2,2-dimethylpent-4-ene 
• 935248-48-9 6-[4-(tert-butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxy)-3,3-dimethyl-butyl]-4-hydroxy-tetrahydropyran-2-one 

Downstream Products

• 935248-51-4 C₃₅H₄₄O₆Si 
• 935248-52-5 C₃₈H₅₀O₆Si 
• 935248-53-6 4-(tert-butyl-diphenyl-silanyloxy)-6-[2-(4-methoxy-benzyloxy)-3,3-dimethyl-4-oxo-hept-6-enyl]-tetrahydro-pyran-2-one 

Relevant academic research and scientific papers

Total syntheses of bryostatins: Synthesis of two ring-expanded bryostatin analogues and the development of a new-generation strategy to access the C7-C27 fragment

Herein, we report the synthesis of novel ring-expanded bryostatin analogues. By carefully modifying the substrate, a selective and high-yielding Ru-catalyzed tandem enyne coupling/Michael addition was employed to construct the northern fragment. Ring-clos

Synthesis of a ring-expanded bryostatin analogue

A ring-expanded bryostatin analogue was synthesized by utilizing a Ru-catalyzed tandem tetrahydropyran formation, a Pd-catalyzed tandem dihydropyran formation, and a ring-closing metathesis (RCM) as key steps. The analogue possesses potent antitumor activ