935263-23-3Relevant articles and documents
Based on xanthene skeleton of PC - Phos chiral shan lin ligands and its full configuration of the preparation method and application (by machine translation)
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Paragraph 0120; 0124; 0145; 0146; 0159, (2018/03/24)
The invention discloses a xanthene skeleton model PC - Phos monophosphine ligand, the ligands of formula (1) compounds of formula or its enantiomer, racemate or non-enantiomer The invention also discloses the preparation method of the ligand, in order to type 2 Formula 4 As raw materials, the substitution reaction, addition reaction, condensation reaction, the reduction reaction of the preparation to the ligand; intercept a 6 Formula 4 As the raw material, a condensation reaction, and The addition reaction to the ligand. The present invention through the use of two configurations deodoration sulfonamide 4 and different types of metal reagent addition reaction, can be obtained by the ligand states chiral shan lin 1 (S, Rs ), 1 (R, Rs ), 1 (S, Ss ) And 1 (R, Ss ) Of four full-configuration of optically pure. The invention also discloses the ligands catalytic connected enamine in the molecule in the asymmetric cyclization reaction of application, has very high reaction activity and stereo selectivity, has wide application value. (by machine translation)