935269-24-2Relevant academic research and scientific papers
7-[1H-Indol-2-yl]-2,3-dihydro-isoindol-1-ones as dual Aurora-A/VEGF-R2 kinase inhibitors: Design, synthesis, and biological activity
Hughes, Terry V.,Emanuel, Stuart L.,O'Grady, Harold R.,Connolly, Peter J.,Rugg, Catherine,Fuentes-Pesquera, Angel R.,Karnachi, Prabha,Alexander, Richard,Middleton, Steven A.
scheme or table, p. 5130 - 5133 (2009/05/26)
A novel series of 7-[1H-indol-2-yl]-2,3-dihydro-isoindol-1-ones designed to be inhibitors of VEGF-R2 kinase was synthesized and found to potently inhibit VEGF-R2 and Aurora-A kinases. The structure-based design, synthesis, and initial SAR of the series are discussed.
SUBSTITUTED DIHYDRO-ISOINDOLONES USEFUL IN TREATING KINASE DISORDERS
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Page/Page column 68, (2008/06/13)
The present invention is directed to novel substituted dihydro-isoindolone compounds of formula (I): and forms thereof, wherein Ring A, X3, R1, R2, R3, R4 and R6 are as herein defined, and their synthesis and use as protein kinase inhibitors and interactions thereof.
