935289-21-7Relevant academic research and scientific papers
Efficient synthesis of benzamide riboside, a potential anticancer agent
Bonnac, Laurent F.,Gao, Guang-Yao,Chen, Liqiang,Patterson, Steven E.,Jayaram, Hiremagalur N.,Pankiewicz, Krzysztof W.
, p. 1249 - 1253 (2007)
An efficient five step synthesis of benzamide riboside (BR) amenable for a large scale synthesis has been developed. It allows for extensive pre-clinical studies of BR as a potential anticancer agent. Copyright Taylor & Francis Group, LLC.
Probing binding requirements of NAD kinase with modified substrate (NAD) analogues
Bonnac, Laurent,Chen, Liqiang,Pathak, Rashmi,Gao, Guangyao,Ming, Qian,Bennett, Eric,Felczak, Krzysztof,Kullberg, Martin,Patterson, Steven E.,Mazzola, Francesca,Magni, Giulio,Pankiewicz, Krzysztof W.
, p. 1512 - 1515 (2007/10/03)
Synthesis of novel NAD+ analogues that cannot be phosphorylated by NAD kinase is reported. In these analogues the C2′ hydroxyl group of the adenosine moiety was replaced by fluorine in the ribo or arabino configuration (1 and 2, respectively) or was inverted into arabino configuration to give compound 3. Compounds 1 and 2 showed inhibition of human NAD kinase, whereas analogue 3 inhibited both the human and Mycobacterium tuberculosis NAD kinase. An uncharged benzamide adenine dinucleotide (BAD) was found to be the most potent competitive inhibitor (Ki = 90 μM) of the human enzyme reported so far.
