935467-97-3

Basic information

• Product Name: TH 237A
• Synonyms: TH 237A;(3R,5S,7aS)-[3,5-Bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl]methanol;meso-GS 164
• CAS NO: 935467-97-3
• Molecular Formula: C18H17F2NO3
• Molecular Weight: 333.3292864
• Mol File: 935467-97-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 90℃ (hexane )
• Boiling Point: 455.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1.40±0.1 g/cm3(Predicted)
• PKA: 15.22±0.10(Predicted)
• CAS DataBase Reference: TH 237A(CAS DataBase Reference)
• NIST Chemistry Reference: TH 237A(935467-97-3)
• EPA Substance Registry System: TH 237A(935467-97-3)

Safety Data

• Hazardous Substances Data: 935467-97-3(Hazardous Substances Data)

Usage

General Description

TH 237A is a chemical compound that belongs to the class of triarylmethane dyes. It is often used as a colorant in various industrial applications, including textile and paper coloring. TH 237A is known for its bright and intense blue color, which makes it desirable for use in dyeing and printing processes. It is also used in the production of paints, inks, and plastics to impart a vibrant blue hue. TH 237A is considered to be a versatile and stable dye, making it a popular choice for a wide range of coloring applications.

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Relevant articles and documents

Synthesis and ring-chain-ring tautomerism of bisoxazolidines, thiazolidinyloxazolidines, and spirothiazolidines

The synthesis of fused heterocycles such as thiazolidinyl-oxazolidine 3 is described starting from Tris·HCl. The mercaptomethyl bisoxazolidine 8 was found to convert to the corresponding thiazolidinyloxazolidine 3 and the spiro-heterocycle 4 by a ring-chain-ring tautomerism, depending on the electronic nature of the ring substituents as well as the reaction conditions. This equilibration pathway is absent in the hydroxymethyl bisoxazolidines 2. Computational studies confirm that both kinetic and thermodynamic control features play a role in the product distribution.

Neuroprotective agents

Novel stereoisomers of GS-164 are provided. The compounds, such as (3R,5S,7as)-(3,5-bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol (TH-237A) and (3R,5S,7as)-(3,5-bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol (T