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935518-90-4

(3-aminomethyl-6-trifluoromethyl-pyridin-2-yl)-benzyl-amine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 935518-90-4 Structure

  • Basic information

    1. Product Name: (3-aminomethyl-6-trifluoromethyl-pyridin-2-yl)-benzyl-amine
    2. Synonyms: (3-aminomethyl-6-trifluoromethyl-pyridin-2-yl)-benzyl-amine
    3. CAS NO:935518-90-4
    4. Molecular Formula:
    5. Molecular Weight: 281.28
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 935518-90-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (3-aminomethyl-6-trifluoromethyl-pyridin-2-yl)-benzyl-amine(CAS DataBase Reference)
    10. NIST Chemistry Reference: (3-aminomethyl-6-trifluoromethyl-pyridin-2-yl)-benzyl-amine(935518-90-4)
    11. EPA Substance Registry System: (3-aminomethyl-6-trifluoromethyl-pyridin-2-yl)-benzyl-amine(935518-90-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 935518-90-4(Hazardous Substances Data)

935518-90-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 935518-90-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,3,5,5,1 and 8 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 935518-90:
(8*9)+(7*3)+(6*5)+(5*5)+(4*1)+(3*8)+(2*9)+(1*0)=194
194 % 10 = 4
So 935518-90-4 is a valid CAS Registry Number.

935518-90-4Relevant articles and documents

2-(3-Fluoro-4-methylsulfonylaminophenyl)propanamides as potent transient receptor potential vanilloid 1 (TRPV1) antagonists: Structure-activity relationships of 2-amino derivatives in the N-(6-trifluoromethylpyridin-3- ylmethyl) C-region

Kim, Myeong Seop,Ryu, Hyungchul,Kang, Dong Wook,Cho, Seong-Hee,Seo, Sejin,Park, Young Soo,Kim, Mi-Yeon,Kwak, Eun Joo,Kim, Yong Soo,Bhondwe, Rahul S.,Kim, Ho Shin,Lee, Jeewoo,Park, Seul-Gi,Son, Karam,Choi, Sun,Deandrea-Lazarus, Ian A.,Pearce, Larry V.,Blumberg, Peter M.,Frank, Robert,Bahrenberg, Gregor,Stockhausen, Hannelore,Koegel, Babette Y.,Schiene, Klaus,Christoph, Thomas

, p. 8392 - 8408,17 (2020/09/15)

A series of N-(2-amino-6-trifluoromethylpyridin-3-ylmethyl)-2-(3-fluoro-4- methylsulfonylaminophenyl)propanamides were designed combining previously identified pharmacophoric elements and evaluated as hTRPV1 antagonists. The SAR analysis indicated that specific hydrophobic interactions of the 2-amino substituents in the C-region of the ligand were critical for high hTRPV1 binding potency. In particular, compound 49S was an excellent TRPV1 antagonist (K i(CAP) = 0.2 nM; IC50(pH) = 6.3 nM) and was thus approximately 100- and 20-fold more potent, respectively, than the parent compounds 2 and 3 for capsaicin antagonism. Furthermore, it demonstrated strong analgesic activity in the rat neuropathic model superior to 2 with almost no side effects. Compound 49S antagonized capsaicin induced hypothermia in mice but showed TRPV1-related hyperthermia. The basis for the high potency of 49S compared to 2 is suggested by docking analysis with our hTRPV1 homology model in which the 4-methylpiperidinyl group in the C-region of 49S made additional hydrophobic interactions with the hydrophobic region.

NOVEL VANILLOID RECEPTOR LIGANDS AND USE THEREOF FOR THE PRODUCTION OF PHARMACEUTICAL PREPARATIONS

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Page/Page column 116-117, (2010/11/27)

The present invention relates to novel vanilloid receptor ligands, to a process for the production thereof, to pharmaceutical preparations containing these compounds and to the use of these compounds for the production of pharmaceutical preparations.

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