935534-40-0

Usage

Uses

Used in Pharmaceutical Research:
2-Bromo-5-fluoro-4-nitropyridine 1-oxide is used as a key intermediate in the synthesis of active pharmaceutical ingredients. Its unique structure and reactivity allow for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Research:
In the agrochemical industry, 2-Bromo-5-fluoro-4-nitropyridine 1-oxide serves as a building block for the synthesis of new chemical entities with pesticidal properties. Its incorporation into agrochemical compounds can lead to the development of more effective and targeted pest control solutions.
Used in Medicinal Chemistry:
2-Bromo-5-fluoro-4-nitropyridine 1-oxide is utilized as a versatile compound in medicinal chemistry for the design and synthesis of novel drug candidates. Its unique functional groups enable the exploration of various chemical modifications, potentially leading to the discovery of new therapeutic agents.
Used in Drug Discovery:
2-Bromo-5-fluoro-4-nitropyridine 1-oxide plays a crucial role in drug discovery processes, where it is employed to identify and optimize potential drug candidates. Its unique properties and reactivity contribute to the development of innovative therapeutic agents with improved efficacy and selectivity.

Upstream product

• 41404-58-4 2-bromo-5-fluoropyridine 
• 935534-39-7 2-bromo-5-fluoro-1-oxido-pyridin-1-ium 

Relevant academic research and scientific papers

STING PYRAZOLE AGONISTS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the modulation of STING, and the treatment of STING-mediated disorders.

MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE

Provided are IDO inhibitor compounds of Formula I and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of diseases. Formula I

Novel 3H-[1,2,3]triazolo[4,5-c]pyridine derivatives as GPR119 agonists: Synthesis and structure-activity/solubility relationships

We previously reported a novel series of 1H-pyrazolo[3,4-c]pyridine derivatives and the identification of compound 4b as a highly potent GPR119 agonist. However, the advancement of preclinical evaluations of compound 4b is expected to be difficult because of the compound's significantly poor aqueous solubility (0.71?μM at pH6.8). In this article, we describe the further optimization of compound 4b focusing on the improvement of its aqueous solubility. Optimization of the central spacer, left-hand aryl group and right-hand piperidine N-capping group led to the identification of a potent GPR119 agonist, 3H-[1,2,3]triazolo[4,5-c]pyridine derivative 32o, with improved solubility (15.9?μM at pH6.8).

PESTICIDALLY ACTIVE POLYCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS

Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.

PESTICIDALLY ACTIVE BI- OR TRICYCLIC HETEROCYCLES WITH SULFUR CONTAINING SUBSTITUENTS

Pesticidally active bi-or tricyclic heterocycles with sulphur-containing substituents, stereoisomers and tautomeric forms thereof that can be used as insecticides and can be prepared in a manner known per se.