93554-83-7

Basic information

• Product Name: 2-AMINO-3-PHENYLPROPIONITRILE HYDROCHLORIDE
• Synonyms: 2-AMINO-3-PHENYLPROPIONITRILE HYDROCHLORIDE;2-AMino-3-phenylpropanenitrile, HCl
• CAS NO: 93554-83-7
• Molecular Formula: C₉H₁₀N₂*ClH
• Molecular Weight: 182.65
• Mol File: 93554-83-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 285.2 °C at 760 mmHg
• Flash Point: 126.3 °C
• Appearance: /
• Vapor Pressure: 0.00284mmHg at 25°C
• CAS DataBase Reference: 2-AMINO-3-PHENYLPROPIONITRILE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3-PHENYLPROPIONITRILE HYDROCHLORIDE(93554-83-7)
• EPA Substance Registry System: 2-AMINO-3-PHENYLPROPIONITRILE HYDROCHLORIDE(93554-83-7)

Safety Data

• Hazardous Substances Data: 93554-83-7(Hazardous Substances Data)

Usage

Hydrochloride form

white crystalline powder
Soluble in water and ethanol
Versatile intermediate in organic synthesis
Commonly used in pharmaceutical industry
Studied for potential use in treatment of neurological disorders
Precursor for synthesis of other organic compounds

InChI:InChI=1/C9H10N2.ClH/c10-7-9(11)6-8-4-2-1-3-5-8;/h1-5,9H,6,11H2;1H

Upstream product

• 143-33-9 sodium cyanide 
• 122-78-1 phenylacetaldehyde 
• 773837-37-9 sodium cyanide 
• 93554-96-2 α-<(trimethylsilyl)oxy>benzenepropanenitrile 
• 151-50-8 potassium cyanide 

Downstream Products

• 87783-72-0 α-benzyl-α-((carbobenzyloxy)glycylamino)acetonitrile 
• 196959-78-1 2-amino-3-benzyl-5-phenylpyrazine 1-oxide 
• 196959-76-9 2-amino-3-benzyl-5-(4-fluorophenyl)pyrazine 1-oxide 
• 671240-54-3 [(1-cyano-2-phenyl-ethylcarbamoyl)-methyl]-carbamic acid tert-butyl ester 
• 1374302-45-0 8-benzyl-6-phenyl-2-(thiophen-2-ylmethyl)imidazo[1,2-a]pyrazin-3(7H)-one 
• 70217-86-6 2-amino-3-benzyl-5-phenyl-pyrazine 
• 1374302-40-5 8-benzyl-2-ethyl-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one 
• 1374302-43-8 8-benzyl-6-phenyl-2-(3,3,3-trifluoropropyl)imidazo[1,2-a]pyrazin-3(7H)-one 
• 70217-85-5 8-benzyl-2-methyl-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one 
• 1374302-41-6 2-((3-benzyl-5-phenylpyrazin-2-yl)amino)butanoic acid 
• 1374302-44-9 5,5,5-trifluoro-2-((3-benzyl-5-phenylpyrazin-2-yl)amino)butanoic acid 
• 1374302-49-4 8-benzyl-2-((1-methyl-1H-imidazol-2-yl)methyl)-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one 
• 24748-46-7 α-benzyl-α-(acetylamino)acetonitrile 
• 151674-85-0 2-Amino-3-benzyl-5-methylpyrazine 1-oxide 

Relevant articles and documents

NOVEL COELENTERAZINE SUBSTRATES AND METHODS OF USE

An isolated polynucleotide encoding a modified luciferase polypeptide and novel coelenterazine- based substrates. The OgLuc variant polypeptide has at least 60% amino acid sequence identity to SEQ ID NO: 1 and at least one amino acid substitution at a position corresponding to an amino acid in SEQ ID NO: 1. The OgLuc variant polypeptide has at least one of enhanced luminescence, enhanced signal stability, and enhanced protein stability relative to the corresponding polypeptide of the wild-type Oplophorus luciferase.

Synthesis and tautomeric equilibrium of 6-amino-5-benzyl-3-methylpyrazin- 2-one. An acceptor-donor-donor nucleoside base analog

6-Aminopyrazin-2-one, when incorporated as pyrimidine base analog into an oligonucleotide, might participate in a nonstandard base pair that retains a Watson-Crick geometry but is joined by a nonstandard hydrogen bonding pattern. Such base pairs can, at least in principle, be recognized independently in duplex nucleic acids. To explore the tautomeric properties that govern hydrogen bonding of this heterocycle, 6-amino-5-benzyl-3- methylpyrazin-2-one was synthesized. The equilibrium constant for the interconversion of the keto and hydroxyl tautomeric forms was estimated by comparing its ultraviolet spectrum with those of N- and O-methyl derivatives in water, methanol, ethanol, dioxane, and water-dioxane mixtures. A plot of the logarithm of the tautomeric equilibrium constant versus Dimroth's microscopic dielectric constant (E(T)(30)) was linear. On the basis of an extrapolation of this relationship to the microscopic dielectric of water, 6- amino-5-benzyl-3-methylpyrazin-2-one is expected to favor at equilibrium the keto form over the hydroxyl form by a factor of ca. 2000 under conditions where DNA and RNA polymerases operate. This is substantially better than the tautomeric ratio observed with isoguanosine, where the minor form has been observed to create tautomeric ambiguity with some polymerase systems.

Heterocycles as Masked Diamide/Dipeptide Equivalents. Formation and Reactions of Substituted 5-(Acylamino)oxazoles as Intermediates en route to the Cyclopeptide Alkaloids

A variety of novel 2,4-dialkyl-5-(acylamino)oxazoles have been prepared by using either amide nitriles or diamides/dipeptides as starting materials.Ring closure calls for the use of trifluoroacetic acid/trifluoroacetic acid anhydride or an acid halide in