935544-47-1

Usage

Uses

Used in Pharmaceutical Industry:
TERT-BUTYL 3-OXOTETRAHYDRO-1H-OXAZOLO[3,4-A]PYRAZINE-7(3H)-CARBOXYLATE is used as a pharmaceutical intermediate for its role in the synthesis of various pharmaceutical drugs. Its unique chemical structure and properties contribute to the development of new medications.
Used in Research and Development:
In the realm of research and development, TERT-BUTYL 3-OXOTETRAHYDRO-1H-OXAZOLO[3,4-A]PYRAZINE-7(3H)-CARBOXYLATE is used to explore its potential therapeutic applications. TERT-BUTYL 3-OXOTETRAHYDRO-1H-OXAZOLO[3,4-A]PYRAZINE-7(3H)-CARBOXYLATE's characteristics make it a subject of interest for scientists looking to innovate and enhance treatment options for different medical conditions.
Used in Drug Synthesis:
TERT-BUTYL 3-OXOTETRAHYDRO-1H-OXAZOLO[3,4-A]PYRAZINE-7(3H)-CARBOXYLATE is used as a key component in the synthesis of drugs, where its reactivity and structural features are leveraged to create effective pharmaceutical agents.
Used in Treatment of Medical Conditions:
While the specific medical conditions are not detailed in the provided materials, TERT-BUTYL 3-OXOTETRAHYDRO-1H-OXAZOLO[3,4-A]PYRAZINE-7(3H)-CARBOXYLATE may have potential applications in the treatment of various medical conditions due to its role in pharmaceutical development. Its use in this context would be for the development of new therapeutic agents that could address unmet medical needs.

Upstream product

• 143540-05-0 2-hydroxymethylpiperazine-1,4-dicarboxylic acid di-tert-butyl ester 
• 181955-79-3 N,N'-di-tert-butyloxycarbonylpiperazine-2-carboxylic acid 
• 129799-08-2 tert-butyl methyl piperazine-1,3-dicarboxylate 
• 301673-16-5 tert-butyl 3-(hydroxymethyl)piperazine-1-carboxylate 
• 530-62-1 1,1'-carbonyldiimidazole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 937047-42-2 hexahydro-oxazolo[3,4-a]pyrazin-3-one 

Downstream Products

• 935544-52-8 tert-butyl 3-((3-fluorophenoxy)methyl)piperazine-1-carboxylate 
• 317365-33-6 1-(benzyloxycarbonyl)-2-hydroxymethyl-4-(tert-butyloxycarbonyl)-piperazine 
• 301673-16-5 tert-butyl 3-(hydroxymethyl)piperazine-1-carboxylate 
• 1020349-31-8 tetrahydrooxazolyl-1H-[3,4-a]pyrazin-3(5H)-one hydrochloride 
• 1609464-42-7 C₂₃H₂₉N₃O₅ 
• 1609464-40-5 C₂₃H₂₈ClN₃O₄ 
• 1609464-38-1 C₂₃H₂₉N₃O₄ 
• 1609464-35-8 C₂₂H₂₆ClN₃O₄ 
• 960535-72-2 C₂₂H₂₇N₃O₄ 
• 1609464-75-6 C₂₉H₃₂N₄O₅ 

Relevant academic research and scientific papers

HETEROAROMATIC DERIVATIVES AND PHARMACEUTICAL APPLICATIONS THEREOF

Disclosed are heteroaryl derivatives, pharmaceutical composition and uses in the manufacture of a medicine for treating respiratory diseases, especially for chronic obstructive pulmonary disease (COPD).

Discovery of novel 2-((pyridin-3-yloxy)methyl)piperazines as α7 nicotinic acetylcholine receptor modulators for the treatment of inflammatory disorders

Herein we report the design, synthesis, and structure-activity relationships for a new class of α7 nicotinic acetylcholine receptor (nAChR) modulators based on the 2-((pyridin-3-yloxy)methyl)piperazine scaffold. The oxazolo[4,5-b]pyridine, (R)-18, and 4-methoxyphenylurea, (R)-47, were identified as potent and selective modulators of the α7 nAChR with favorable in vitro safety profiles and good oral bioavailability in mouse. Both compounds were shown to significantly inhibit cellular infiltration in a murine model of allergic lung inflammation. Despite the structural and in vivo functional similarities in the compounds, only (R)-18 was shown to be an agonist. Compound (R)-47 demonstrated silent agonist activity. These data support the hypothesis that the anti-inflammatory activity of the α7 nAChR is mediated by a signal transduction pathway that is independent of ion current.

An orthogonal protection strategy for the synthesis of 2-substituted piperazines

Tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-ones are readily prepared from the bis-carbamate protected piperazine-2-carboxylic acids and serve as orthogonally protected piperazines from which a variety of 2-substituted piperazines can be prepared. Sodium benzylate and sodium phenoxides react at the C-5 carbon of the oxazolidinone to yield 2-(benzyloxymethyl)piperazines and 2-(phenoxymethyl)piperazines, respectively. The tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-ones also provide convenient scaffolds from which 2-benzyl- and 2-phenethylpiperazines are prepared.

NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF

Disclosed are novel piperazine derivatives that act as agonists of the α7 nAChR. Also disclosed are phannaceutical compositions, methods of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds.