93560-81-7Relevant academic research and scientific papers
The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors
Tumey, L. Nathan,Bom, David,Huck, Bayard,Gleason, Elizabeth,Wang, Jianmin,Silver, Daniel,Brunden, Kurt,Boozer, Sherry,Rundlett, Stephen,Sherf, Bruce,Murphy, Steven,Dent, Tom,Leventhal, Christina,Bailey, Andrew,Harrington, John,Bennani, Youssef L.
, p. 277 - 281 (2007/10/03)
We describe the identification and SAR of a series of low nanomolar inhibitors of FEN1, an enzyme involved in DNA repair pathways. These inhibitors have been shown to sensitize certain cell lines to DNA damage. Flap endonuclease-1 (FEN1) is a key enzyme i
Synthesis of new ethyl 3-amino-4-arylfuran-2-carboxylates
Lisowski, Vincent,Vu, Duc Nghia,Feng, Xiao,Rault, Sylvain
, p. 753 - 756 (2007/10/03)
An efficient method for the preparation of new ethyl 3-amino-4-arylfuran-2-carboxylates is described. The synthesis proceeds via the corresponding hydroxyacrylonitrile sodium salt and an intermediate malonate vinyl ether. The last step of ring closure aff
Synthesis of 2-Acyl-3-aminofurans by Thorpe Cyclization
Gewald, Karl,Bellmann, Peter,Jaensch, Hans-Joachim
, p. 1702 - 1710 (2007/10/02)
The substituted β-(acylmethoxy)acrylonitriles 2 and 11, obtainable by O-alkylation of β-cyano ketones with halomethyl ketones or by the reaction of α-hydroxymethyl ketones with β-chloro-α-cyanocinnamonitrile are cyclized in the presence of bases to yield
