935684-22-3

Upstream product

• 10288-24-1 3-methyl-4-hydroxy-2-cyclopentenone 
• 935684-26-7 (4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-iodo-3-methylcyclopent-2-en-1-one 
• 935684-12-1 4-{[tert-butyl(dimethyl)silyl]oxy}-2-iodo-3-methylcyclopent-2-en-1-one 
• 935684-23-4 4-[tert-butyl(dimethyl)silyl]oxy-3-methylcyclopent-2-en-1-one 
• 935684-25-6 (R)-4-hydroxy-3-methylcyclopent-2-en-1-one 
• 935684-21-2 (1R,4R)-4-(tert-butyldimethylsilanyloxy)-2-iodo-3-methylcyclopent-2-en-1-ol 
• 2251-50-5 pentafluorobenzoylchloride 

Downstream Products

• 966-47-2 3-methoxy-estra-1,3,5⁽¹⁰⁾,8⁽⁹⁾,14⁽¹⁵⁾-pentaene-17-one 

Relevant academic research and scientific papers

Formal enantioselective synthesis of (+)-estrone

(Chemical Equation Presented) A formal total synthesis of (+)-estrone (4% overall yield; ca. 12 steps) could be achieved via the Torgov diene. An asymmetric allylic substitution is the key step for the construction of the chiral quaternary carbon center of a synthetic intermediate which was converted in four steps to the Torgov diene.