935696-55-2Relevant academic research and scientific papers
DNA binding, photocleavage, antimicrobial and cytotoxic properties of Ru(II) polypyridyl complexes containing BOPIP ligand, (BOPIP = {2-(4-(benzyloxy) phenyl)-1H-imidazo [4,5-f] [1,2]phenanthroline})
Gopu, Srinivas,Ravi kumar, Vuradi,Laxma Reddy, Kotha,Venkat Reddy, Putta,Sirasani, Satyanarayana
, p. 349 - 373 (2019)
A novel ligand BOPIP (BOPIP = {2-(4-(benzyloxy)phenyl)-1H-imidazo[4,5-f][1,10]phenanthroline}) and its mononuclear Ru(II) polypyridyl complexes [Ru(phen)2 BOPIP]2+(1) (phen = 1,10-Phenanthrolene), [Ru(bpy)2 BOPIP]2+/
Synthesis, characterization and biological activities of ciprofloxacin drug based metal complexes
Patel, Mohan N.,Dosi, Promise A.,Bhatt, Bhupesh S.
, p. 622 - 631 (2012/11/14)
The interaction of small molecules with DNA has attracted a great deal of attention. Mixed ligand copper(II) complexes of type [Cu(cpf)(Ln)Cl] [cpf = ciprofloxacin, Ln = phenanthroline derivatives] were synthesized and characterized by elemental analysis, reflectance, IR and mass spectra. Viscosity measurements, absorption titration and DNA melting temperature studies were employed to determine the mode of binding of complexes with DNA. DNA cleavage study showed better cleaving ability of the complexes compare to metal salts and standard drug. The SOD mimic study showed IC 50 value of complexes in the range of 0.95 to 1.75 μM. Antibacterial activity was assayed against selective Gram(-ve) and Gram(+ve) microorganisms.
