935753-08-5Relevant academic research and scientific papers
Asymmetric hydroamination of acrylonitrile derivatives catalyzed by Ni(II)-complexes
Fadini, Luca,Togni, Antonio
, p. 2555 - 2562 (2008)
Chiral ferrocenyl tridentate phosphine ligands were synthesized and used in asymmetric hydroamination reactions catalyzed by Ni(II)-complexes. Compounds of the type [Ni(PPP)L]2+, where L is a chloride, solvent molecule or a coordinated substrate, were isolated. The efficiency of these complexes in asymmetric catalysis was high when aliphatic or aromatic amines were reacted with electron-poor olefins, especially with acrylonitrile derivatives. This hydroamination reaction affords up to 95% enantioselectivity at -80 °C for the addition of morpholine to methacrylonitrile (69% ee at room temperature).
