935759-71-0

Basic information

• Product Name: 5-(2-fluorophenyl)-4-oxo-N-[(3-{[3-(1H-1,2,4-triazol-3-yloxy)propyl]oxy}phenyl)methyl]-3,4-dihydrothieno[2,3-d]-pyrimidine-2-carboxamide
• CAS NO: 935759-71-0
• Molecular Weight: 520.544
• Mol File: 935759-71-0.mol

Chemical Properties

• CAS DataBase Reference: 5-(2-fluorophenyl)-4-oxo-N-[(3-{[3-(1H-1,2,4-triazol-3-yloxy)propyl]oxy}phenyl)methyl]-3,4-dihydrothieno[2,3-d]-pyrimidine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-fluorophenyl)-4-oxo-N-[(3-{[3-(1H-1,2,4-triazol-3-yloxy)propyl]oxy}phenyl)methyl]-3,4-dihydrothieno[2,3-d]-pyrimidine-2-carboxamide(935759-71-0)
• EPA Substance Registry System: 5-(2-fluorophenyl)-4-oxo-N-[(3-{[3-(1H-1,2,4-triazol-3-yloxy)propyl]oxy}phenyl)methyl]-3,4-dihydrothieno[2,3-d]-pyrimidine-2-carboxamide(935759-71-0)

Safety Data

• Hazardous Substances Data: 935759-71-0(Hazardous Substances Data)

Upstream product

• 873-62-1 m-cyanophenol 
• 935760-53-5 3-[(3-{[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]oxy}-propyl)oxy]benzonitrile 
• 935760-59-1 5-(2-fluorophenyl)-4-oxo-N-({3-[(3-{[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]oxy}propyl)oxy]phenyl}methyl)-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxamide 
• 445-27-2 2'-Fluoroacetophenone 
• 849659-32-1 ethyl 2-amino-4-(2-fluorophenyl)thiophene-3-carboxylate 
• 935760-39-7 ethyl 5-(2-fluorophenyl)-4-oxo-3,4-dihydrothieno[2,3-d]-pyrimidine-2-carboxylate 

Relevant articles and documents

Discovery of novel, highly potent, and selective matrix metalloproteinase (MMP)-13 inhibitors with a 1,2,4-triazol-3-yl moiety as a zinc binding group using a structure-based design approach

On the basis of a superposition study of X-ray crystal structures of complexes of quinazoline derivative 1 and triazole derivative 2 with matrix metalloproteinase (MMP)-13 catalytic domain, a novel series of fused pyrimidine compounds which possess a 1,2,4-triazol-3-yl group as a zinc binding group (ZBG) was designed. Among the herein described and evaluated compounds, 31f exhibited excellent potency for MMP-13 (IC50 = 0.036 nM) and selectivities (greater than 1,500-fold) over other MMPs (MMP-1, -2, -3, -7, -8, -9, -10, and -14) and tumor necrosis factor-α converting enzyme (TACE). Furthermore, the inhibitor was shown to protect bovine nasal cartilage explants against degradation induced by interleukin-1 and oncostatin M. In this article, we report the discovery of extremely potent, highly selective, and orally bioavailable fused pyrimidine derivatives that possess a 1,2,4-triazol-3-yl group as a novel ZBG for selective MMP-13 inhibition.

HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF

The present invention provides a novel amide compound represented by the following formula, which has a matrix metalloproteinase inhibitory activity and is useful as a pharmaceutical agent. wherein each symbol is as defined in the specification.