93579-03-4

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 21473-01-8 2-naphthalenylmagnesium bromide 

Downstream Products

• 37859-25-9 2-naphthylacetyl chloride 
• 954410-31-2 methyl 3-[1-{[1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-4-(2-naphthyl)piperidin-4-yl]propanoate 
• 954410-29-8 benzyl 4-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]-4-(2-naphthyl)piperidine-1-carboxylate 
• 954409-71-3 1-[(benzyloxy)carbonyl]-4-(2-naphthyl)piperidine-4-carboxylic acid 
• 954409-69-9 benzyl 4-formyl-4-(2-naphthyl)piperidine-1-carboxylate 
• 954409-68-8 1-benzyl 4-tert-butyl 4-(2-naphthyl)piperidine-1,4-dicarboxylate 

Relevant academic research and scientific papers

Iron-catalyzed chemoselective cross-coupling of α-bromocarboxylic acid derivatives with aryl grignard reagents

We have developed a simple and effective synthetic method of α-arylcarboxylic acid derivatives based on the iron-catalyzed cross-coupling reaction of α-bromocarboxylic acid derivatives with aryl Grignard reagents. The reaction proceeds smoothly at -78 °C in a chemoselective manner to produce the coupling product in good to excellent yields.