935846-39-2

Upstream product

• 95-56-7 2-hydroxybromobenzene 
• 73183-34-3 bis(pinacol)diborane 
• 824-94-2 p-methoxybenzyl chloride 
• 533-58-4 2-Iodophenol 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 637301-05-4 4-methoxybenzyl 2’-iodophenyl ether 

Downstream Products

• 935846-40-5 ethyl 3-[2-(4-methoxybenzyloxy)phenyl]indole-2-carboxylate 
• 935846-41-6 ethyl 7-bromo-3-[2-(4-methoxybenzyloxy)phenyl]indole-2-carboxylate 
• 70794-13-7 2-(1H-indol-3-yl)phenol 
• 935846-46-1 ethyl 1-allyloxycarbonyl-7-bromo-3-[2-(4-methoxybenzyloxy)phenyl]-2-oxoindole-3-carboxylate 
• 935846-45-0 ethyl 1-allyloxycarbonyl-3-[2-(4-methoxybenzyloxy)phenyl]-2-oxoindole-3-carboxylate 
• 935846-44-9 ethyl 1-(tert-butoxycarbonyl)-3-[2-(4-methoxybenzyloxy)phenyl]-2-oxoindole-3-carboxylate 
• 935846-43-8 ethyl 7-bromo-3-[2-(4-methoxybenzyloxy)phenyl]-2-oxoindole-3-carboxylate 
• 935846-42-7 ethyl 3-[2-(4-methoxybenzyloxy)phenyl]-2-oxoindole-3-carboxylate 

Relevant academic research and scientific papers

WNT PATHWAY MODULATORS

The application relates to a 2,6-dioxo-purine derivative, 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(6-(2-hydroxyphenyl)pyridazin-3-yl)acetamide, and the use of this compound in the modulation of the Wnt pathway, and treating a disease

Oxidative rearrangement of Indoles: A new approach to the EFHG-tetracyclic core of diazonamide A

(Chemical Equation Presented) A new approach to the ring EFHG-tetracyclic core fragment of the marine secondary metabolite diazonamide A is described. The route is based on the oxidative rearrangement of 3-arylindole-2-carboxylates. Thus, a range of 3-arylindole-2-carboxylates (3, 8) underwent rearrangement to the corresponding 3,3-disubstituted oxindoles (4, 9) with migration of the ester group upon treatment with tert-butyl hypochlorite followed by acid. The oxindoles 9 with a 3-[2-(4-methoxybenzyloxy)]phenyl substituent underwent cyclization to the tetracyclic aminals 11 following N-protection, reduction, and treatment with methanesulfonic anhydride. The methodology was applied to the tyrosine-indole derivative 17 to give the EFHG-tetracyclic core of diazonamide A.