Helospectin II is a neurotoxin derived from the venom of the spider Agelena orientalis, consisting of 32 amino acid residues. It specifically targets and blocks certain types of calcium channels in the nervous system, causing paralysis and death in potential prey. Structurally similar to omega-agatoxin IVA, helospectin II offers unique binding properties and activity, contributing to the understanding of venom toxicity and the development of pharmaceuticals targeting calcium channels.
93585-83-2
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Basic information
- Product Name: helospectin II
- Synonyms: HelospectinI, 38-de-L-serine-; 10: PN: WO0077039 TABLE: 1 unclaimed protein; 10: PN:WO2004005342 PAGE: 46 claimed protein; 3: PN: WO0234285 SEQID: 11 claimedprotein; 6: PN: US6284725 SEQID: 11 unclaimed protein; 6: PN: WO0066138 PAGE:13 unclaimed protein; 6: PN: WO0066142 TABLE: 1 unclaimed protein; L-Serine,L-histidyl-L-seryl-L-a-aspartyl-L-alanyl-L-threonyl-L-phenylalanyl-L-threonyl-L-alanyl-L-a-glutamyl-L-tyrosyl-L-seryl-L-lysyl-L-leucyl-L-leucyl-L-alanyl-L-lysyl-L-leucyl-L-alanyl-L-leucyl-L-glutaminyl-L-lysyl-L-tyrosyl-L-leucyl-L-a-glutamyl-L-seryl-L-isoleucyl-L-leucylglycyl-L-seryl-L-seryl-L-threonyl-L-seryl-L-prolyl-L-arginyl-L-prolyl-L-prolyl-
- CAS NO:93585-83-2
- Molecular Formula: C180H288N46O57
- Molecular Weight: 4008.48672
- EINECS: N/A
- Product Categories: N/A
- Mol File: 93585-83-2.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: helospectin II(CAS DataBase Reference)
- NIST Chemistry Reference: helospectin II(93585-83-2)
- EPA Substance Registry System: helospectin II(93585-83-2)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 93585-83-2(Hazardous Substances Data)
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93585-83-2 Usage
Uses
Used in Pharmaceutical Development:Helospectin II is used as a research tool for studying the mechanisms of venom toxicity and the function of calcium channels in the nervous system. Its unique binding properties and activity provide valuable insights for the development of new pharmaceuticals targeting calcium channels.
Used in Neurological Research:
Helospectin II is used as a neurotoxin in neurological research to investigate the role of calcium channels in various neurological processes and disorders. Its ability to specifically target and block certain calcium channels allows researchers to study the effects of these channels on neuronal function and potential therapeutic interventions.
Used in Drug Discovery:
Helospectin II is used as a lead compound in drug discovery for the development of novel calcium channel blockers. Its structural similarity to other calcium channel blockers, such as omega-agatoxin IVA, offers a basis for designing new molecules with improved binding properties and therapeutic potential.
Used in Venom Therapy:
Helospectin II is used in venom therapy as a potential therapeutic agent for treating neurological disorders by targeting and modulating the activity of specific calcium channels in the nervous system. Its ability to selectively block certain calcium channels may offer targeted treatment options for conditions such as chronic pain, epilepsy, and neurodegenerative diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 93585-83-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,3,5,8 and 5 respectively; the second part has 2 digits, 8 and 3 respectively.Calculate Digit Verification of CAS Registry Number 93585-83:
(7*9)+(6*3)+(5*5)+(4*8)+(3*5)+(2*8)+(1*3)=172
172 % 10 = 2
So 93585-83-2 is a valid CAS Registry Number.
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