93591-86-7

Upstream product

• 1445-73-4 1-Methyl-4-piperidone 
• 106-49-0 p-toluidine 
• 99918-50-0 N-(1-methylpiperidylidene-4)-p-toluidine 

Downstream Products

• 202859-54-9 N-piperidin-4-yl-N-p-tolyl-propionamide 
• 1807-12-1 N-(4-Methylphenyl)-N-<1-(2-phenylethyl)-4-piperidyl>propanamide Hydrochloride 
• 310408-47-0 3-(3-diethoxymethyl-4-nitrophenyl)-2,5-dimethyl-1-(1-methyl-4-piperidinyl)-1H-indole 
• 310408-56-1 N'-[2-(3-[1,3]dioxolan-2-yl-4-nitro-phenyl)-1-methyl-ethylidene]-N-(1-methyl-piperidin-4-yl)-N-p-tolyl-hydrazine 
• 310408-20-9 N¹-(1-methyl-4-piperidinyl)-4-toluylhydrazine 
• 310408-52-7 5-[2,5-dimethyl-1-(1-methyl-4-piperidinyl)-1H-indol-3-yl]-2-nitrobenzaldehyde 
• 99918-59-9 [5-Methyl-2-(1-methyl-piperidin-4-ylamino)-phenyl]-phenyl-methanone 
• 96524-55-9 {2-[(2-Chloro-phenyl)-imino-methyl]-4-methyl-phenyl}-(1-methyl-piperidin-4-yl)-amine 

Relevant academic research and scientific papers

Radiosynthesis of [18F]Lu29-024: a potential PET ligand for brain imaging of the serotonergic 5-HT2 receptor.

In a previous work, Lu29-024 (2,5-dimethyl-3-(4-fluorophenyl)-1-(1-methyl-4-piperidinyl)-1H-indole), a selective 5-HT2A receptor antagonist with nanomolar affinity and high selectivity, was labeled with carbon-11 to evaluate its behavior as a potential PET ligand for the serotonergic 5-HT2A receptor in the central nervous system. Administration of this tracer to rats was followed by a good brain uptake, no brain labeled metabolites but no specific, regio-selective, binding at 20 and 40 min post injection. Despite this, the data noted at 20 and 40 min suggest that this tracer, if associated with a radioactive emitter with a longer half-life than that of carbon-11, could be useful for the quantification of 5HT2A receptors. For these reasons, we chose to label this compound, bearing a fluorine atom, with [18F]fluoride, in order to perform rat studies over a more prolonged time-scale. The precursor for the radiosynthesis of [18F]Lu29-024 was obtained in an overall yield of 20% by a multi-step synthesis including an acetonylation reaction followed by a Fisher indole reaction. The radiotracer was prepared by an aromatic substitution with activated [18F]fluoride followed by a decarbonylation reaction that employed Wilkinson's catalyst. The radiosynthesis of [18F]Lu29-024 required approximatively 110 min with an overall radiochemical yield of 20-35% and specific activities of 37GBq/micromol. Fluorine-labeled Lu29-024 may thus be envisaged as a potentially useful PET tracer that can be applied to a wide range of neurological and psychiatric diseases.

Structure-activity studies of fentanyl

The preparation of analogues of fentanyl with para substituents in the anilino aromatic ring, anilino nitrogen separated from phenyl by methylene or bimethylene, and phenacyl replacing propionyl as the N-acyl substituent is reported. Although all para sub

Aminohaloborane in Organic Synthesis. IX. Exclusive ortho Acylation Reaction of N-Monoaminoalkylanilines

The exclusive ortho acylation reaction of aniline derivatives using boron trichloride made possible the one-step synthesis of 2-acyl-N-monoaminoalkylanilines (1) and the corresponding imines (2) from N-monoaminoalkylanilines, even in the case of compounds with a bulky substituent at the nitrogen atom.Conventional methods only give 1 via elaborate procedures.Keywords: regioselective reaction; 2-acylaniline derivative; 2-acylaniline-imine derivative; boron trichloride