93593-08-9

Upstream product

• 41292-86-8 4-methoxyphenyl-(1-methyl-piperidin-4-yl)-amine 
• 394-47-8 2-fluorobenzonitrile 
• 104-94-9 4-methoxy-aniline 
• 1445-73-4 1-Methyl-4-piperidone 

Downstream Products

• 93592-82-6 2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-N-[2-(2-fluoro-benzoyl)-4-methoxy-phenyl]-N-(1-methyl-piperidin-4-yl)-acetamide 
• 93592-72-4 5-(2-Fluoro-phenyl)-7-methoxy-1-(1-methyl-piperidin-4-yl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one 

Relevant academic research and scientific papers

Aminohaloborane in Organic Synthesis. IX. Exclusive ortho Acylation Reaction of N-Monoaminoalkylanilines

The exclusive ortho acylation reaction of aniline derivatives using boron trichloride made possible the one-step synthesis of 2-acyl-N-monoaminoalkylanilines (1) and the corresponding imines (2) from N-monoaminoalkylanilines, even in the case of compounds with a bulky substituent at the nitrogen atom.Conventional methods only give 1 via elaborate procedures.Keywords: regioselective reaction; 2-acylaniline derivative; 2-acylaniline-imine derivative; boron trichloride