93593-11-4

Upstream product

• 1445-73-4 1-Methyl-4-piperidone 
• 106-47-8 4-chloro-aniline 
• 394-47-8 2-fluorobenzonitrile 
• 36796-53-9 N-(4-chlorophenyl)-1-methylpiperidin-4-amine 

Downstream Products

• 93592-75-7 7-chloro-5-(2-fluorophenyl)-1-(1-methyl-4-piperidinyl)-1,3-dihydro-1,4-benzodiazepin-2-one 
• 93592-56-4 7-chloro-1,3-dihydro-5-(2-fluorophenyl)-1-(4-piperidinyl)-2H-1,4-benzodiazepin-2-one 
• 96110-94-0 4-[3-Acetoxy-7-chloro-5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-piperidine-1-carboxylic acid benzyl ester 
• 96129-00-9 4-[7-Chloro-5-(2-fluoro-phenyl)-2-oxo-4-oxy-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-piperidine-1-carboxylic acid benzyl ester 
• 93592-55-3 1-(1-benzyloxycarbonyl-4-piperidinyl)-7-chloro-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one 
• 93592-52-0 4-[4-chloro-2-(2-fluorobenzoyl)anilino]-1-benzyloxycarbonylpiperidine 
• 96110-73-5 4-[7-Chloro-5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-piperidine-1-carboxylic acid ethyl ester 
• 96110-75-7 7-chloro-1,3-dihydro-5-(2-fluorophenyl)-3-hydroxy-1-(1-methyl-4-piperidinyl)-2H-1,4-benzodiazepin-2-one 
• 96110-74-6 7-chloro-1,3-dihydro-5-(2-fluorophenyl)-3-hydroxy-1-(4-piperidinyl)-2H-1,4-benzodiazepin-2-one 
• 96110-88-2 [5-Chloro-2-(piperidin-4-ylamino)-phenyl]-(2-fluoro-phenyl)-methanone 
• 93592-50-8 4-[4-chloro-2-(2-fluoro-benzoyl)anilino]-1-ethoxycarbonylpiperidine 

Relevant academic research and scientific papers

Aminohaloborane in Organic Synthesis. IX. Exclusive ortho Acylation Reaction of N-Monoaminoalkylanilines

The exclusive ortho acylation reaction of aniline derivatives using boron trichloride made possible the one-step synthesis of 2-acyl-N-monoaminoalkylanilines (1) and the corresponding imines (2) from N-monoaminoalkylanilines, even in the case of compounds with a bulky substituent at the nitrogen atom.Conventional methods only give 1 via elaborate procedures.Keywords: regioselective reaction; 2-acylaniline derivative; 2-acylaniline-imine derivative; boron trichloride

Aminohaloborane in Organic Synthesis. X. A Convenient, Economical Exclusive ortho Substitution Reaction of N-Alkyl and N-Aminoalkyl Anilines

A method for in situ generation of boron trichloride from boron trifluoride etherate and silicon tetrachloride in the presence of triethylamine, traced by boron-11 nuclear magnetic resonance (11B-NMR) spectroscopy, was successfully developed, thus elimina