936007-02-2Relevant academic research and scientific papers
Synthesis of Chiral Triarylmethanes Bearing All-Carbon Quaternary Stereocenters: Catalytic Asymmetric Oxidative Cross-Coupling of 2,2-Diarylacetonitriles and (Hetero)arenes
Wang, Zehua,Zhu, Yasheng,Pan, Xiaoguang,Wang, Gang,Liu, Lei
supporting information, p. 3053 - 3057 (2020/02/05)
A direct and enantioselective oxidative cross-coupling of racemic 2,2-diarylacetonitriles with electron-rich (hetero)arenes has been described, which allows for efficient construction of triarylmethanes bearing all-carbon quaternary stereocenters with excellent chemo- and enantioselectivity. The reaction has an excellent functional group tolerance, and exhibits a broad scope with respect to both 2,2-diarylacetonitrile and (hetero)arene components. The rich chemistry of the cyano group allows for facile synthesis of other valuable chiral triarylmethanes bearing all-carbon quaternary centers that are otherwise difficult to access.
Effect of substituents on diarylmethanes for antitubercular activity
Panda, Gautam,Parai, Maloy Kumar,Das, Sajal Kumar,Shagufta,Sinha, Manish,Chaturvedi, Vinita,Srivastava, Anil K.,Manju,Gaikwad, Anil N.,Sinha, Sudhir
, p. 410 - 419 (2008/02/02)
Aminoalkyl derivatives of diarylmethanes were prepared using Grignard, Friedel-Crafts arylation and aminohydrochloride chain formation reactions. These series of compounds were evaluated against Mycobacterium tuberculosis H37Rv and s
