936024-79-2Relevant academic research and scientific papers
Synthesis of ferrocene tethered open and macrocyclic bis-β-lactams and bis-β-amino acid derivatives
Sierra, Miguel A.,Rodriguez-Fernandez, Mamen,Casarrubios, Luis,Gomez-Gallego, Mar,Allen, Charles P.,Mancheno, Maria Jose
, p. 8399 - 8405 (2009)
New bioorganometallic ferrocene derivatives are synthesized through a Diversity Oriented Synthesis strategy. Easily available ferrocene bisimines have been transformed into open ferrocenyl bis-β-lactams. These compounds have demonstrated to be versatile s
Further solvent-free reactions of ferrocenylaldehydes: Synthesis of 1,1′-ferrocenyldiimines and ferrocenylacrylonitriles
Imrie, Christopher,Kleyi, Phumelele,Nyamori, Vincent O.,Gerber, Thomas I.A.,Levendis, Demetrius C.,Look, Jennifer
, p. 3443 - 3453 (2008/02/12)
Grinding of 1,1′-ferrocenedicarboxaldehyde with a 2.2 molar equivalent of an aromatic amine in a solvent-free environment provided excellent yields of 1,1′-ferrocenyldiimines. After mixing the aldehyde and amines, a gum or melt formed which eventually solidified to the product. An analytically pure sample of the product was obtained by cold recrystallization. Grinding of ferrocenecarboxaldehyde and 4-substituted phenylacetonitriles under solvent-free conditions provided good yields of the corresponding ferrocenylacrylonitriles. The yield in this reaction was very low when the substituent group para to the acetonitrile group was electron-donating.
Synthesis and characterization of 1,1′-bis[(N-methyl-N-phenyl)aminomethyl(ethyl)]ferrocenes. Crystal structures of [Fe{(η5-C5H4)-C(C6H 5){double bond, long}N-CH2C6H4CH3-4} 2] and 2[Fe{(η5-C5H4)-CH2N (CH3)...
Wang, Hong-Xing,Gao, Ren-Qing,Yang, Xiao-Li,Wan, Li,Wu, Hong-Fei,Geng, Feng-Ying,Jin, Rong
, p. 1037 - 1044 (2008/10/09)
Title full: Synthesis and characterization of 1,1′-bis[(N-methyl-N-phenyl)aminomethyl(ethyl)]ferrocenes. Crystal structures of [Fe{(η5-C5H4)-C(C6H 5){double bond, long}N-CH2C6H4CH3-4} 2] and 2[Fe{(η5-C5H4)-CH2N (CH3)-C6H4OCH3-4}2] · 1/4H2O. Direct or catalytic condensation of diacylferrocenes (acyl = formyl, acetyl, and benzoyl) and anilines or benzylamines with titanium tetrachloride as a catalyst resulted in the corresponding diimines 1-3, respectively. Reduction of these imines with sodium borohydride or lithium aluminum hydride/aluminum chloride in THF yielded 1,1′-bis[(N-phenyl)aminomethyl(ethyl)]ferrocenes (4, 5) and 1,1′-bis[(N-benzyl)aminobenzyl]ferrocenes (6), respectively. Reductive methylation of 4-6 with aqueous formaldehyde, cyanoborohydride and acetic acid only afforded 1,1′-bis[(N-methyl-N-phenyl)aminomethyl(ethyl)]ferrocenes (7, 8). 1,1′-Bis[{(N-methyl-N-benzyl)amino}benzyl]ferrocenes (9) were not obtained, probably due to their debenzylation under the acidic conditions. The molecular structures of 3g and 7a were determined by single crystal X-ray analysis.
