93604-96-7

Basic information

• Product Name: C₃₀H₃₉N₃O₁₅P₂
• CAS NO: 93604-96-7
• Molecular Weight: 743.598
• Mol File: 93604-96-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₀H₃₉N₃O₁₅P₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₀H₃₉N₃O₁₅P₂(93604-96-7)
• EPA Substance Registry System: C₃₀H₃₉N₃O₁₅P₂(93604-96-7)

Safety Data

• Hazardous Substances Data: 93604-96-7(Hazardous Substances Data)

Upstream product

• 57099-40-8 17-hydroxy-21-phosphonooxy-pregna-1,4-diene-3,11,20-trione 
• 69467-87-4 Morpholin-4-yl-phosphonic acid mono-[(2R,3S,4S,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester; compound with N,N'-dicyclohexyl-morpholine-4-carboxamidine 
• 55786-16-8 21-iodoprednisone 
• 53-03-2 Prednison 

Relevant articles and documents

Nucleoside conjugates. 6. Synthesis and comparison of antitumor activity of 1-β-D-arabinofuranosylcytosine conjugates of corticosteroids and selected lipophilic alcohols

Five new P1-(steroid-21-yl)-P2-(1-β-D-arabinofuranosylcytosin-5'-yl)pyrophosphat es (ara-CDP-steroids), five 1-β-D-arabinofuranosylcytosine 5'-O-(alkyl)phosphates (ara-CMP-alkyl esters), and two P1-(alkyl)-P2-(1-β-D-arabinofuranosylcytosin-5'-yl)pyrophosphate (ara-CDP-alkyl esters) have been prepared and evaluated against L1210 lymphoid leukemia in culture and in mice (C3D2F1/J). These include ara-CDP-11-deoxycorticosterone, ara-CDP-cortisone, ara-CDP-corticosterone, ara-CDP-cortexolone, and ara-CDP-prednisone, ara-CMP hexadecyl ester, ara-CMP 1-cyclohexylmethyl ester, ara-CMP 1-adamantylmethyl ester, ara-CMP 2-(1-adamanthyl)ethyl ester, ara-CMP 2-chloroethyl ester, ara-CDP hexadecyl ester, and ara-CDP 1-cyclohexylmethyl ester. The in vitro antitumor results indicated that ara-CDP-steroids were as active as the previously reported ara-CMP-steroids and that ara-CMP and ara-CDP-alkyl esters were less growth inhibiting than ara-CDP-steroids and ara-C. However, the in vivo antitumor results indicated that ara-CDP-steroids were generally less effective than the previous monophosphate derivatives. Among them ara-CDP-corticosterone and the known ara-CDP-cortisol showed greater efficacy than ara-C with ILS value of 152% and 209%, respectively, at the optimal dose of 40 and 80 (mg/kg)/day for 9 days, while that of ara-C was 138% at the optimum dose of 9.2 (mg/kg)/day. Generally, ara-CMP alkyl esters, given ip to the L1210 leukemic mice, were found to be toxic and ineffective. However, ara-CDP hexadecyl ester showed marginal activity (ILS, 38%). These preliminary results support the thesis that the ara-C conjugates of this type may require a lipophilic and naturally occurring moiety for improved efficacy.