936077-12-2

Basic information

• Product Name: 8-amino-6-(2,3-dimethoxyphenyl)-2-(methylamino)-5-oxo-6-phenyl-5,6-dihydro-4H-pyrano[2,3-d][1,3]thiazolo[4,5-b]pyridine-7-carbonitrile
• Synonyms: 8-amino-6-(2,3-dimethoxyphenyl)-2-(methylamino)-5-oxo-6-phenyl-5,6-dihydro-4H-pyrano[2,3-d][1,3]thiazolo[4,5-b]pyridine-7-carbonitrile
• CAS NO: 936077-12-2
• Molecular Weight: 411.441
• Mol File: 936077-12-2.mol

Chemical Properties

• CAS DataBase Reference: 8-amino-6-(2,3-dimethoxyphenyl)-2-(methylamino)-5-oxo-6-phenyl-5,6-dihydro-4H-pyrano[2,3-d][1,3]thiazolo[4,5-b]pyridine-7-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 8-amino-6-(2,3-dimethoxyphenyl)-2-(methylamino)-5-oxo-6-phenyl-5,6-dihydro-4H-pyrano[2,3-d][1,3]thiazolo[4,5-b]pyridine-7-carbonitrile(936077-12-2)
• EPA Substance Registry System: 8-amino-6-(2,3-dimethoxyphenyl)-2-(methylamino)-5-oxo-6-phenyl-5,6-dihydro-4H-pyrano[2,3-d][1,3]thiazolo[4,5-b]pyridine-7-carbonitrile(936077-12-2)

Safety Data

• Hazardous Substances Data: 936077-12-2(Hazardous Substances Data)

Upstream product

• 626226-54-8 LDN-0089404 
• 109-77-3 malononitrile 
• 86-51-1 2,3-dimethyoxybenzaldehyde 

Relevant articles and documents

Synthesis of substituted thiazolo[4,5-b]pyridines and other annulated heterocycles via SN2→Thorpe-Ziegler→Thorpe-Guareschi domino reactions

A new combinatorial method for the preparation of substituted thiazolo[4,5-b]pyridines, which utilizes cyanoacetamide, heterocumulenes (isothiocyanates, carbon bisulfide), and ethyl-4-chloroacetoacetate in a new SN2→Thorpe-Ziegler→Thorpe-Guareschi domino reactions has been developed. The obtained thiazolo[4,5-b]pyridines were then used together with aldehydes and malononitrile in another Knoevenagel reaction→Michael reaction→hetero-Thorpe-Ziegler domino reaction for the synthesis of substituted 4,6-dihydro-5H-pyrano[2,3-d]thiazolo[4,5-b]pyridines.