936098-12-3

Upstream product

• 292638-85-8 acrylic acid methyl ester 
• 174265-12-4 2-bromo-5-chlorobenzaldehyde 

Downstream Products

• 936098-13-4 methyl 3-[4-chloro-2-(hydroxymethyl)phenyl]propanoate 
• 1229445-75-3 (E)-methyl 3-(2-(2,2-dibromovinyl)-4-chlorophenyl)acrylate 

Relevant academic research and scientific papers

COMPOUNDS ACT AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE

The present invention provides compounds, that areN-alkyl-2-(l-(5-substituted-2-(3- oxo-3-(trifluoromethylsulfonamido)propyl)benzyl)pyrrolidin-2-yl)oxazole-4-carboxamide wherein the 5 substituent is selected from the group consisting of halo and alkyloxy

FATTY ACID AMIDE HYDROLASE INHIHIBITORS FOR TREATING PAIN

Compounds of Formula 1 are described herein. These compounds may be administered to a patient for treatment of suffering from pain or other FAAH mediated conditions.

A tandem catalytic approach to methyleneindenes: Mechanistic insights into gem -dibromoolefin reactivity

(Figure presented) The methylenindene scaffold can be prepared from readily available gem-dibromoolefins using an efficient palladium-catalyzed tandem intermolecular Suzuki/intramolecular Heck reaction. The reaction is highly modular and proceeds under mild conditions. The choice of ligand was found to be crucial to control the selectivity of the reaction. Isolation of intermediates under different conditions provides insight into the mechanism.

Novel Compounds

The invention relates to substituted aryl acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.