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Upstream product

• 1006-94-6 5-methoxylindole 
• 122-51-0 orthoformic acid triethyl ester 
• 149-73-5 trimethyl orthoformate 

Relevant academic research and scientific papers

Tris(indolyl)methene molecule as an anion receptor and colorimetric chemosensor: Tunable selectivity and sensitivity for anions

Simple tris(indolyl)methene receptors 1-3 containing conjugated bisindole skeletons have been designed and synthesized. The anion binding and sensing properties have been studied using UV-vis spectroscopy and 1H NMR titration technique. Compared with 3,3′-bis-indolyl phenylmethene (4), tris(indolyl)methene receptors could highly selectively detect F- based on two stages of proton transfer, along with stepwise drastic color changes. The introduction of the electron withdrawing or donating groups into indole unit, which tunes the acidities of the hydrogen bond sites, partially enhanced or inhibited the occurrence of the deprotonation of receptor and has a positive effect on the selectivity and sensitivity of such "proton- transfer" chemosensors for anions.

One-pot solvent-free synthesis of triaryl- and triheteroarylmethanes by Bi(OTf)3-catalyzed Friedel-Crafts reaction of arenes/heteroarenes with trialkyl orthoformates

A convenient, practical and highly efficient one-pot method has been developed for the synthesis of triaryl- and triheteroarylmethane derivatives by Bi(OTf)3-catalyzed Friedel-Crafts alkylation of trialkyl orthoformates in combination with a wide variety of arenes/heteroarenes at room temperature under solvent-free conditions and in an air atmosphere. The methodology offers an operational simplicity, high atom economy and environmentally benign procedure. Furthermore, selected compound 3k showed promising anti-inflammatory activity with inhibition nitric oxide and did not exhibit significant cytotoxic effects on macrophage cells.

An expeditious and efficient synthesis of symmetrical tris(indolyl)methanes under catalyst-free conditions in fluorinated alcohols

Hexafluoro-2-propanol (HFIP) is explored as an effective medium for the synthesis of symmetrical tris(indolyl)methanes through the reaction of indole derivatives with orthoesters at room temperature. The solvent (HFIP) can be readily separated from reaction products and recovered in excellent purity for direct reuse.

Efficient and convenient method for the synthesis of symmetrical triindolylmethanes catalyzed by iodine

Indoles reacted with triethyl orthoformate in the presence of a catalytic amount of iodine at room temperature to give the corresponding symmetrical triindolylmethanes (TIMs) in good to high yields. Copyright Taylor & Francis Group, LLC.