93614-63-2Relevant academic research and scientific papers
New phosphonate reagents for aldehyde homologation
Petroski, Richard J.
, p. 3841 - 3854 (2007)
New phosphonate reagents were developed for the two-carbon homologation of aldehydes to unbranched or methyl-branched unsaturated aldehydes. The phosphonate reagents, diethyl methylformylphosphonate dimethylhydrazone and diethyl ethylformyl-2-phosphonate dimethylhydrazone, contained a protected aldehyde group instead of the usual ester group. A homologation cycle entailed condensation of the reagent with the starting aldehyde, followed by removal of the dimethylhydrazone protective group with a biphasic mixture of 1 M HCl and petroleum ether. This robust two-step process worked with aliphatic, α,β-unsaturated and aromatic aldehydes. Isolated yields for the condensation step ranged from 77% to 89%, and yields for the deprotection step ranged from 81% to 96%. Copyright Taylor & Francis Group, LLC.
Method for preparing olefine aldehyde by catalyzing terminal alkyne or terminal conjugated eneyne and diphosphine ligand used in method
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Paragraph 0183-0187, (2021/05/29)
The invention discloses a method for preparing olefine aldehyde by catalyzing terminal alkyne or terminal conjugated eneyne and a diphosphine ligand used in the method. According to the invention, indole-substituted phosphoramidite diphosphine ligand which is stable in air and insensitive to light is synthesized by utilizing a continuous one-pot method, and the indole-substituted phosphoramidite diphosphine ligand and a rhodium catalyst are used for jointly catalyzing to successfully achieve a hydroformylation reaction of aromatic terminal alkyne and terminal conjugated eneyne under the condition of synthesis gas for the first time, so that an olefine aldehyde structure compound can be rapidly and massively prepared, and particularly, a polyolefine aldehyde structure compound which is more difficult to synthesize in the prior art can be easily prepared and synthesized, and a novel method is provided for synthesis and modification of drug molecules, intermediates and chemical products.
A Novel and General Route to 1-Iodo-2,4(E,E)-dienes via Pentadienyl Dithiocarbamate
Hayashi, Toshio,Sasaoka, Kazuo,Oishi, Takeshi
, p. 1362 - 1363 (2007/10/02)
The title compounds were prepared from pentadienyl dithiocarbamate via S-methylathion and by use of the iodide an unsymmetric, all-trans-conjugated pentaene was synthesized.
