93618-46-3Relevant academic research and scientific papers
Cascade regioselective synthesis of pyrazoles from nitroallylic acetates and N-tosyl hydrazine
Shao, Nana,Chen, Tong,Zhang, Taotao,Zhu, Huajian,Zheng, Qunxiong,Zou, Hongbin
, p. 795 - 799 (2014)
A simple, practical, and regioselective synthetic protocol for the formation of pyrazoles was developed. Unlike all other previously reported reactions of nitroallylic acetates, this process was initiated by a S N2 reaction at the electrophilic γ site. A plausible mechanism for the cascade SN2-Michael synthesis is proposed.
