936231-26-4

Basic information

• Product Name: 5-ethyl-5-methyl-4-oxo-4,5-dihydro-furan-2-carboxylic acid methyl ester
• CAS NO: 936231-26-4
• Molecular Weight: 184.192
• Mol File: 936231-26-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-ethyl-5-methyl-4-oxo-4,5-dihydro-furan-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ethyl-5-methyl-4-oxo-4,5-dihydro-furan-2-carboxylic acid methyl ester(936231-26-4)
• EPA Substance Registry System: 5-ethyl-5-methyl-4-oxo-4,5-dihydro-furan-2-carboxylic acid methyl ester(936231-26-4)

Safety Data

• Hazardous Substances Data: 936231-26-4(Hazardous Substances Data)

Upstream product

• 77-75-8 meparfynol 
• 936231-46-8 2-(2-methyl-[1,3]dithian-2-yl)-butan-2-ol 
• 109916-61-2 3-hydroxy-3-methyl-pentan-2-one 
• 18370-95-1 methyl 2,2,2-trimethoxyacetate 

Relevant articles and documents

Analogues of Acifran: Agonists of the high and low affinity niacin receptors, GPR109a and GPR109b

Recently identified GPCRs, GPR109a and GPR109b, the high and low affinity receptors for niacin, may represent good targets for the development of HDL elevating drugs for the treatment of atherosclerosis. Acifran, an agonist of both receptors, has been tested in human subjects, yet until recently very few analogs had been reported. We describe a series of acifran analogs prepared using newly developed synthetic pathways and evaluated as agonists for GPR109a and GPR109b, resulting in identification of compounds with improved activity at these receptors.